Muscle sodium channel inactivation defect in paramyotonia congenita with the thr1313met mutation.


Journal Article

Mutations of the skeletal muscle sodium (Na) channel have been reported in families with paramyotonia congenita (PC), an autosomal dominant disorder with cold and/or exercise induced stiffness and myotonia. Functional consequences of specific Na channel mutations responsible for PC have not been described. Patch clamp recording of single Na channels were made in cultured myotubes at 22 and 34 degrees C from a PC patient with the thr1313met mutation. Cell-attached and outside-out recordings of mutant PC channels contained long duration and late openings. The mean open time was increased and the ensemble average showed a prolonged inward Na current. This membrane depolarization could cause repetitive action potentials and the clinical syndrome.

Full Text

Cited Authors

  • Tahmoush, AJ; Schaller, KL; Zhang, P; Hyslop, T; Heiman-Patterson, T; Caldwell, JH

Published Date

  • September 1, 1994

Published In

Volume / Issue

  • 4 / 5-6

Start / End Page

  • 447 - 454

PubMed ID

  • 7533571

Pubmed Central ID

  • 7533571

International Standard Serial Number (ISSN)

  • 0960-8966

Digital Object Identifier (DOI)

  • 10.1016/0960-8966(94)90083-3


  • eng

Conference Location

  • England