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Risk of necrotizing enterocolitis in very-low-birth-weight infants with isolated atrial and ventricular septal defects.

Publication ,  Journal Article
Bain, J; Benjamin, DK; Hornik, CP; Clark, R; Smith, PB
Published in: J Perinatol
April 2014

OBJECTIVE: Necrotizing enterocolitis (NEC) is associated with a significant morbidity and mortality in premature infants. We sought to identify the frequency of NEC in very-low-birth-weight infants with isolated ventricular septal defects (VSDs) or atrial septal defects (ASDs) using a large multicenter database. STUDY DESIGN: We identified a cohort of infants with birth weight <1500 g cared for in 312 neonatal intensive care units (NICUs) managed by the Pediatrix Medical Group between 1997 and 2010. We examined the association between the presence of an ASD or a VSD with development of NEC using logistic regression to control for small-for-gestational age status, antenatal steroid use, antenatal antibiotic use, gestational age, sex, race, Apgar score at 5 min and method of delivery. RESULT: Of the 98 523 infants who met inclusion criteria, 1904 (1.9%) had an ASD, 1943 (2.0%) had a VSD and 146 (0.1%) had both. The incidence of NEC was 6.2% in infants without septal defects, 9.3% in those with an ASD, 7.8% in those with a VSD, and 10.3% in infants with both an ASD and a VSD. Compared with infants without septal defects, the adjusted odds ratios for developing NEC for each group-ASD alone, VSD alone and ASD with VSD-were 1.26 (95% confidence interval 1.07 to 1.49), 1.27 (1.07 to 1.51) and 1.79 (1.03 to 3.12), respectively. CONCLUSION: The presence of an ASD or a VSD was associated with NEC in this cohort of premature infants.

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Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

April 2014

Volume

34

Issue

4

Start / End Page

319 / 321

Location

United States

Related Subject Headings

  • Pediatrics
  • Odds Ratio
  • Infant, Very Low Birth Weight
  • Humans
  • Heart Septal Defects, Ventricular
  • Heart Septal Defects, Atrial
  • Gestational Age
  • Enterocolitis, Necrotizing
  • Comorbidity
  • 3213 Paediatrics
 

Citation

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ICMJE
MLA
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Bain, J., Benjamin, D. K., Hornik, C. P., Clark, R., & Smith, P. B. (2014). Risk of necrotizing enterocolitis in very-low-birth-weight infants with isolated atrial and ventricular septal defects. J Perinatol, 34(4), 319–321. https://doi.org/10.1038/jp.2013.174
Bain, J., D. K. Benjamin, C. P. Hornik, R. Clark, and P. B. Smith. “Risk of necrotizing enterocolitis in very-low-birth-weight infants with isolated atrial and ventricular septal defects.J Perinatol 34, no. 4 (April 2014): 319–21. https://doi.org/10.1038/jp.2013.174.
Bain J, Benjamin DK, Hornik CP, Clark R, Smith PB. Risk of necrotizing enterocolitis in very-low-birth-weight infants with isolated atrial and ventricular septal defects. J Perinatol. 2014 Apr;34(4):319–21.
Bain, J., et al. “Risk of necrotizing enterocolitis in very-low-birth-weight infants with isolated atrial and ventricular septal defects.J Perinatol, vol. 34, no. 4, Apr. 2014, pp. 319–21. Pubmed, doi:10.1038/jp.2013.174.
Bain J, Benjamin DK, Hornik CP, Clark R, Smith PB. Risk of necrotizing enterocolitis in very-low-birth-weight infants with isolated atrial and ventricular septal defects. J Perinatol. 2014 Apr;34(4):319–321.

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

April 2014

Volume

34

Issue

4

Start / End Page

319 / 321

Location

United States

Related Subject Headings

  • Pediatrics
  • Odds Ratio
  • Infant, Very Low Birth Weight
  • Humans
  • Heart Septal Defects, Ventricular
  • Heart Septal Defects, Atrial
  • Gestational Age
  • Enterocolitis, Necrotizing
  • Comorbidity
  • 3213 Paediatrics