Integrated efficacy to effectiveness trials.

Journal Article (Journal Article)

Experts in clinical research, therapeutic development, and comparative effectiveness are continually frustrated in their attempts to fit the square peg of therapeutic development into the round hole of clinical trials. Trials can be optimized to provide signals in highly controlled experiments or to estimate an intervention's effect in poorly controlled real-world settings, but not both simultaneously. Selker and colleagues propose a continuum that creates a smooth transition from controlled experiments to real-world, real-time studies within a single mechanism.

Full Text

Duke Authors

Cited Authors

  • Califf, RM

Published Date

  • February 2014

Published In

Volume / Issue

  • 95 / 2

Start / End Page

  • 131 - 133

PubMed ID

  • 24448458

Electronic International Standard Serial Number (EISSN)

  • 1532-6535

Digital Object Identifier (DOI)

  • 10.1038/clpt.2013.232

Language

  • eng

Conference Location

  • United States