Chronic spinal cord electrical stimulation protects against 6-hydroxydopamine lesions.

Journal Article (Journal Article)

Although L-dopa continues to be the gold standard for treating motor symptoms of Parkinson's disease (PD), it presents long-term complications. Deep brain stimulation is effective, but only a small percentage of idiopathic PD patients are eligible. Based on results in animal models and a handful of patients, dorsal column stimulation (DCS) has been proposed as a potential therapy for PD. To date, the long-term effects of DCS in animal models have not been quantified. Here, we report that DCS applied twice a week in rats treated with bilateral 6-OHDA striatal infusions led to a significant improvement in symptoms. DCS-treated rats exhibited a higher density of dopaminergic innervation in the striatum and higher neuronal cell count in the substantia nigra pars compacta compared to a control group. These results suggest that DCS has a chronic therapeutical and neuroprotective effect, increasing its potential as a new clinical option for treating PD patients.

Full Text

Duke Authors

Cited Authors

  • Yadav, AP; Fuentes, R; Zhang, H; Vinholo, T; Wang, C-H; Freire, MAM; Nicolelis, MAL

Published Date

  • January 23, 2014

Published In

Volume / Issue

  • 4 /

Start / End Page

  • 3839 -

PubMed ID

  • 24452435

Pubmed Central ID

  • PMC3899601

Electronic International Standard Serial Number (EISSN)

  • 2045-2322

Digital Object Identifier (DOI)

  • 10.1038/srep03839


  • eng

Conference Location

  • England