Acute graft-versus-host disease: are we close to bringing the bench to the bedside?

Journal Article (Review)

Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplant (AHSCT) associated with significant morbidity and mortality. This review focuses on the pathophysiology, prevention, and treatment of acute GVHD. Specifically, we explain how new discoveries in immunology have expanded our understanding of GVHD, in which tissue damage from chemotherapy or radiation results in cytokine release, activating T cells, resulting in proliferation and differentiation, trafficking to target organs, and tissue destruction and inflammation. Insights into the mechanisms of this disease relate directly to the development of preventive strategies and therapies, such as immunosuppression, calcineurin inhibitors, T-cell depletion, CCR5 antagonists, gut decontamination, extracorporeal photopheresis, and more. Understanding the immunobiology of GVHD and developing effective preventions and treatments are critical to the continuing success of AHSCT.

Full Text

Duke Authors

Cited Authors

  • Sung, AD; Chao, NJ

Published Date

  • September 2013

Published In

Volume / Issue

  • 26 / 3

Start / End Page

  • 285 - 292

PubMed ID

  • 24309532

Electronic International Standard Serial Number (EISSN)

  • 1532-1924

International Standard Serial Number (ISSN)

  • 1521-6926

Digital Object Identifier (DOI)

  • 10.1016/j.beha.2013.10.009

Language

  • eng