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Acute graft-versus-host disease: are we close to bringing the bench to the bedside?

Publication ,  Journal Article
Sung, AD; Chao, NJ
Published in: Best Pract Res Clin Haematol
September 2013

Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplant (AHSCT) associated with significant morbidity and mortality. This review focuses on the pathophysiology, prevention, and treatment of acute GVHD. Specifically, we explain how new discoveries in immunology have expanded our understanding of GVHD, in which tissue damage from chemotherapy or radiation results in cytokine release, activating T cells, resulting in proliferation and differentiation, trafficking to target organs, and tissue destruction and inflammation. Insights into the mechanisms of this disease relate directly to the development of preventive strategies and therapies, such as immunosuppression, calcineurin inhibitors, T-cell depletion, CCR5 antagonists, gut decontamination, extracorporeal photopheresis, and more. Understanding the immunobiology of GVHD and developing effective preventions and treatments are critical to the continuing success of AHSCT.

Duke Scholars

Published In

Best Pract Res Clin Haematol

DOI

EISSN

1532-1924

Publication Date

September 2013

Volume

26

Issue

3

Start / End Page

285 / 292

Location

Netherlands

Related Subject Headings

  • Transplantation, Homologous
  • T-Lymphocytes
  • Receptors, CCR5
  • Photopheresis
  • Lymphocyte Depletion
  • Lymphocyte Activation
  • Immunosuppression Therapy
  • Immunology
  • Immunologic Factors
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sung, A. D., & Chao, N. J. (2013). Acute graft-versus-host disease: are we close to bringing the bench to the bedside? Best Pract Res Clin Haematol, 26(3), 285–292. https://doi.org/10.1016/j.beha.2013.10.009
Sung, Anthony D., and Nelson J. Chao. “Acute graft-versus-host disease: are we close to bringing the bench to the bedside?Best Pract Res Clin Haematol 26, no. 3 (September 2013): 285–92. https://doi.org/10.1016/j.beha.2013.10.009.
Sung AD, Chao NJ. Acute graft-versus-host disease: are we close to bringing the bench to the bedside? Best Pract Res Clin Haematol. 2013 Sep;26(3):285–92.
Sung, Anthony D., and Nelson J. Chao. “Acute graft-versus-host disease: are we close to bringing the bench to the bedside?Best Pract Res Clin Haematol, vol. 26, no. 3, Sept. 2013, pp. 285–92. Pubmed, doi:10.1016/j.beha.2013.10.009.
Sung AD, Chao NJ. Acute graft-versus-host disease: are we close to bringing the bench to the bedside? Best Pract Res Clin Haematol. 2013 Sep;26(3):285–292.
Journal cover image

Published In

Best Pract Res Clin Haematol

DOI

EISSN

1532-1924

Publication Date

September 2013

Volume

26

Issue

3

Start / End Page

285 / 292

Location

Netherlands

Related Subject Headings

  • Transplantation, Homologous
  • T-Lymphocytes
  • Receptors, CCR5
  • Photopheresis
  • Lymphocyte Depletion
  • Lymphocyte Activation
  • Immunosuppression Therapy
  • Immunology
  • Immunologic Factors
  • Humans