Risk factors for Staphylococcus aureus nasal colonization in Danish middle-aged and elderly twins

Journal Article

Staphylococcus aureus is a human commensal bacterium found in the nasal cavity and other body sites. Identifying risk factors for S. aureus nasal carriage is of interest, as nasal carriage is a risk factor for subsequent invasive infection. We recently investigated the influence of host genetics on S. aureus carriage in Danish middle-aged and elderly twins, which indicated no significant heritability that could account for the observed S. aureus carriage. In the present study, we performed a questionnaire-based study of S. aureus colonization on the same cohort of 2,196 Danish middle-aged and elderly twins to identify specific risk factors for S. aureus nasal colonization, including analyzing the paired twins (n = 478) that were discordant for S. aureus colonization. We found associations between risk factors and S. aureus nasal colonization among middle-aged and elderly twins, including age, male gender, psoriasis, and atopic diseases. Also, present living on a farm is clearly associated with S. aureus colonization, while smoking had a borderline statistically significant protective effect. © 2013 The Author(s).

Full Text

Duke Authors

Cited Authors

  • Andersen, PS; Larsen, LA; Jr, VGF; Stegger, M; Skov, RL; Christensen, K

Published Date

  • 2013

Published In

Volume / Issue

  • 32 / 10

Start / End Page

  • 1321 - 1326

International Standard Serial Number (ISSN)

  • 0934-9723

Digital Object Identifier (DOI)

  • 10.1007/s10096-013-1882-0