Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors.

Journal Article (Journal Article;Review)

The pathophysiology of vasoocclusion is thought to involve a wide variety of adhesive interactions involving erythrocytes, leukocytes, and the endothelium. Selectins are expressed by leukocytes, platelets, and the endothelium, among other tissues. They contribute to a wide variety of physiologically important cell-cell interactions, including adhesion of all types of blood cells to the endothelium. In vitro, in vivo, and early-phase clinical studies suggest that E-selectin and pan-selectin inhibitors may be promising new therapeutic agents for the treatment of vasoocclusion in sickle cell disease.

Full Text

Duke Authors

Cited Authors

  • Telen, MJ

Published Date

  • April 2014

Published In

Volume / Issue

  • 28 / 2

Start / End Page

  • 341 - 354

PubMed ID

  • 24589270

Electronic International Standard Serial Number (EISSN)

  • 1558-1977

Digital Object Identifier (DOI)

  • 10.1016/j.hoc.2013.11.010


  • eng

Conference Location

  • United States