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Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors.

Publication ,  Journal Article
Telen, MJ
Published in: Hematol Oncol Clin North Am
April 2014

The pathophysiology of vasoocclusion is thought to involve a wide variety of adhesive interactions involving erythrocytes, leukocytes, and the endothelium. Selectins are expressed by leukocytes, platelets, and the endothelium, among other tissues. They contribute to a wide variety of physiologically important cell-cell interactions, including adhesion of all types of blood cells to the endothelium. In vitro, in vivo, and early-phase clinical studies suggest that E-selectin and pan-selectin inhibitors may be promising new therapeutic agents for the treatment of vasoocclusion in sickle cell disease.

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Published In

Hematol Oncol Clin North Am

DOI

EISSN

1558-1977

Publication Date

April 2014

Volume

28

Issue

2

Start / End Page

341 / 354

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • L-Selectin
  • Humans
  • Glycolipids
  • Endothelium, Vascular
  • Endothelial Cells
  • E-Selectin
  • Cell Communication
  • Cell Adhesion
  • Arterial Occlusive Diseases
 

Citation

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Telen, M. J. (2014). Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors. Hematol Oncol Clin North Am, 28(2), 341–354. https://doi.org/10.1016/j.hoc.2013.11.010
Telen, Marilyn J. “Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors.Hematol Oncol Clin North Am 28, no. 2 (April 2014): 341–54. https://doi.org/10.1016/j.hoc.2013.11.010.
Telen MJ. Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors. Hematol Oncol Clin North Am. 2014 Apr;28(2):341–54.
Telen, Marilyn J. “Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors.Hematol Oncol Clin North Am, vol. 28, no. 2, Apr. 2014, pp. 341–54. Pubmed, doi:10.1016/j.hoc.2013.11.010.
Telen MJ. Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors. Hematol Oncol Clin North Am. 2014 Apr;28(2):341–354.
Journal cover image

Published In

Hematol Oncol Clin North Am

DOI

EISSN

1558-1977

Publication Date

April 2014

Volume

28

Issue

2

Start / End Page

341 / 354

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • L-Selectin
  • Humans
  • Glycolipids
  • Endothelium, Vascular
  • Endothelial Cells
  • E-Selectin
  • Cell Communication
  • Cell Adhesion
  • Arterial Occlusive Diseases