Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody.

Journal Article (Journal Article)

Regulatory T cells (Tregs) play a central role in in tumor escape from immunosurveillance. We report that a bispecific T-cell engager (BiTE) targeting a mutated form of the epidermal growth factor receptor, i.e., EGFRvIII, potently redirects Tregs to kill glioblastoma through the granzyme-perforin pathway.

Full Text

Duke Authors

Cited Authors

  • Choi, BD; Gedeon, PC; Sanchez-Perez, L; Bigner, DD; Sampson, JH

Published Date

  • December 1, 2013

Published In

Volume / Issue

  • 2 / 12

Start / End Page

  • e26757 -

PubMed ID

  • 24475376

Pubmed Central ID

  • PMC3891636

International Standard Serial Number (ISSN)

  • 2162-4011

Digital Object Identifier (DOI)

  • 10.4161/onci.26757


  • eng

Conference Location

  • United States