Molecular control of steady-state dendritic cell maturation and immune homeostasis.

Journal Article (Journal Article;Review)

Dendritic cells (DCs) are specialized sentinels responsible for coordinating adaptive immunity. This function is dependent upon coupled sensitivity to environmental signs of inflammation and infection to cellular maturation-the programmed alteration of DC phenotype and function to enhance immune cell activation. Although DCs are thus well equipped to respond to pathogens, maturation triggers are not unique to infection. Given that immune cells are exquisitely sensitive to the biological functions of DCs, we now appreciate that multiple layers of suppression are required to restrict the environmental sensitivity, cellular maturation, and even life span of DCs to prevent aberrant immune activation during the steady state. At the same time, steady-state DCs are not quiescent but rather perform key functions that support homeostasis of numerous cell types. Here we review these functions and molecular mechanisms of suppression that control steady-state DC maturation. Corruption of these steady-state operatives has diverse immunological consequences and pinpoints DCs as potent drivers of autoimmune and inflammatory disease.

Full Text

Duke Authors

Cited Authors

  • Hammer, GE; Ma, A

Published Date

  • 2013

Published In

Volume / Issue

  • 31 /

Start / End Page

  • 743 - 791

PubMed ID

  • 23330953

Pubmed Central ID

  • PMC4091962

Electronic International Standard Serial Number (EISSN)

  • 1545-3278

Digital Object Identifier (DOI)

  • 10.1146/annurev-immunol-020711-074929


  • eng

Conference Location

  • United States