The final touches make perfect the peptide-MHC class I repertoire.

Journal Article (Journal Article;Review)

Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved peptides on the cell surface for immune surveillance by CD8(+) T cells. The pathway for generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I) repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by dynamic interactions within the MHC peptide-loading complex. Failure to customize the pMHC I repertoire has profound immunological consequences.

Full Text

Duke Authors

Cited Authors

  • Hammer, GE; Kanaseki, T; Shastri, N

Published Date

  • April 2007

Published In

Volume / Issue

  • 26 / 4

Start / End Page

  • 397 - 406

PubMed ID

  • 17459809

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2007.04.003


  • eng

Conference Location

  • United States