The final touches make perfect the peptide-MHC class I repertoire.
Journal Article (Journal Article;Review)
Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved peptides on the cell surface for immune surveillance by CD8(+) T cells. The pathway for generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I) repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by dynamic interactions within the MHC peptide-loading complex. Failure to customize the pMHC I repertoire has profound immunological consequences.
Full Text
Duke Authors
Cited Authors
- Hammer, GE; Kanaseki, T; Shastri, N
Published Date
- April 2007
Published In
Volume / Issue
- 26 / 4
Start / End Page
- 397 - 406
PubMed ID
- 17459809
International Standard Serial Number (ISSN)
- 1074-7613
Digital Object Identifier (DOI)
- 10.1016/j.immuni.2007.04.003
Language
- eng
Conference Location
- United States