Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge.


Journal Article (Review)

We have extended our understanding of the molecular biology that underlies adult glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents have remained a relatively under-investigated disease. The latest large-scale genomic and epigenomic profiling studies have yielded an unprecedented abundance of novel data and provided deeper insights into gliomagenesis across all age groups, which has highlighted key distinctions but also some commonalities. As we are on the verge of dissecting glioblastomas into meaningful biological subgroups, this Review summarizes the hallmark genetic alterations that are associated with distinct epigenetic features and patient characteristics in both paediatric and adult disease, and examines the complex interplay between the glioblastoma genome and epigenome.

Full Text

Cited Authors

  • Sturm, D; Bender, S; Jones, DTW; Lichter, P; Grill, J; Becher, O; Hawkins, C; Majewski, J; Jones, C; Costello, JF; Iavarone, A; Aldape, K; Brennan, CW; Jabado, N; Pfister, SM

Published Date

  • February 2014

Published In

Volume / Issue

  • 14 / 2

Start / End Page

  • 92 - 107

PubMed ID

  • 24457416

Pubmed Central ID

  • 24457416

Electronic International Standard Serial Number (EISSN)

  • 1474-1768

International Standard Serial Number (ISSN)

  • 1474-175X

Digital Object Identifier (DOI)

  • 10.1038/nrc3655


  • eng