Traversing the basement membrane in vivo: a diversity of strategies.

Journal Article (Review;Journal Article)

The basement membrane is a dense, highly cross-linked, sheet-like extracellular matrix that underlies all epithelia and endothelia in multicellular animals. During development, leukocyte trafficking, and metastatic disease, cells cross the basement membrane to disperse and enter new tissues. Based largely on in vitro studies, cells have been thought to use proteases to dissolve and traverse this formidable obstacle. Surprisingly, recent in vivo studies have uncovered a remarkably diverse range of cellular- and tissue-level strategies beyond proteolysis that cells use to navigate through the basement membrane. These fascinating and unexpected mechanisms have increased our understanding of how cells cross this matrix barrier in physiological and disease settings.

Full Text

Duke Authors

Cited Authors

  • Kelley, LC; Lohmer, LL; Hagedorn, EJ; Sherwood, DR

Published Date

  • February 2014

Published In

Volume / Issue

  • 204 / 3

Start / End Page

  • 291 - 302

PubMed ID

  • 24493586

Pubmed Central ID

  • PMC3912525

Electronic International Standard Serial Number (EISSN)

  • 1540-8140

International Standard Serial Number (ISSN)

  • 0021-9525

Digital Object Identifier (DOI)

  • 10.1083/jcb.201311112


  • eng