Copper-catalyzed α-amination of phosphonates and phosphine oxides: a direct approach to α-amino phosphonic acids and derivatives.
Journal Article (Journal Article)
A direct approach to important α-amino phosphonic acids and its derivatives has been developed by using copper-catalyzed electrophilic amination of α-phosphonate zincates with O-acyl hydroxylamines. This amination provides the first example of CN bond formation which directly introduces acyclic and cyclic amines to the α-position of phosphonates in one step. The reaction is readily promoted at room temperature with as little as 0.5 mol % of catalyst, and demonstrates high efficiency on a broad substrate scope.
Full Text
Duke Authors
Cited Authors
- McDonald, SL; Wang, Q
Published Date
- February 2014
Published In
Volume / Issue
- 53 / 7
Start / End Page
- 1867 - 1871
PubMed ID
- 24474326
Electronic International Standard Serial Number (EISSN)
- 1521-3773
International Standard Serial Number (ISSN)
- 1433-7851
Digital Object Identifier (DOI)
- 10.1002/anie.201308890
Language
- eng