Copper-catalyzed α-amination of phosphonates and phosphine oxides: a direct approach to α-amino phosphonic acids and derivatives.

Journal Article (Journal Article)

A direct approach to important α-amino phosphonic acids and its derivatives has been developed by using copper-catalyzed electrophilic amination of α-phosphonate zincates with O-acyl hydroxylamines. This amination provides the first example of CN bond formation which directly introduces acyclic and cyclic amines to the α-position of phosphonates in one step. The reaction is readily promoted at room temperature with as little as 0.5 mol % of catalyst, and demonstrates high efficiency on a broad substrate scope.

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Duke Authors

Wang, Qiu

Cited Authors

McDonald, SL; Wang, Q

Published Date

February 2014

Published In

Angewandte Chemie International Edition

Volume / Issue

53 / 7

Start / End Page

1867 - 1871

PubMed ID

24474326

Electronic International Standard Serial Number (EISSN)

1521-3773

International Standard Serial Number (ISSN)

1433-7851

Digital Object Identifier (DOI)

10.1002/anie.201308890

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