Oral and injectable non-insulin antidiabetic medications are important components of outpatient management of type 2 diabetes. They are effective and safe for plasma glucose. However, even when patients have good glycemic control at home on these medications, it is essential to evaluate their safety and utility for the management of inpatient hyperglycemia. Factors that govern glucose stability are variable for inpatients: diet and physical activity level, planned and unplanned procedures, acute/critical illness, and unexpected complications. © 2011 Springer Science+Business Media, LLC.