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The BB diabetic rat. Profound T-cell lymphocytopenia.

Publication ,  Journal Article
Jackson, R; Rassi, N; Crump, T; Haynes, B; Eisenbarth, GS
Published in: Diabetes
October 1981

Approximately 50% of Wistar "BB" rats spontaneously develop overt diabetes mellitus characterized by loss of beta-cells and "insulitis." To define abnormalities of immunoregulation in these rats, we quantitated their major circulating lymphocyte subsets. Independent of the development of diabetes, we found the BB rats to have a markedly increased percentage of circulating B lymphocytes which is secondary to a severe T-cell lymphocytes which is secondary to a severe T-cell lymphocytopenia, with the major circulating T-cell subset reacting with monoclonal antibody W3/25 markedly decreased. This lymphocytopenia is present in every animal studied and contrasted with studies of the nondiabetic Wistar strain from which the "BB" rats were developed.

Duke Scholars

Published In

Diabetes

DOI

ISSN

0012-1797

Publication Date

October 1981

Volume

30

Issue

10

Start / End Page

887 / 889

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Rats, Inbred Strains
  • Rats
  • Male
  • Lymphocyte Depletion
  • Leukocyte Count
  • Female
  • Endocrinology & Metabolism
  • Diabetes Mellitus
  • B-Lymphocytes
 

Citation

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ICMJE
MLA
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Jackson, R., Rassi, N., Crump, T., Haynes, B., & Eisenbarth, G. S. (1981). The BB diabetic rat. Profound T-cell lymphocytopenia. Diabetes, 30(10), 887–889. https://doi.org/10.2337/diab.30.10.887
Jackson, R., N. Rassi, T. Crump, B. Haynes, and G. S. Eisenbarth. “The BB diabetic rat. Profound T-cell lymphocytopenia.Diabetes 30, no. 10 (October 1981): 887–89. https://doi.org/10.2337/diab.30.10.887.
Jackson R, Rassi N, Crump T, Haynes B, Eisenbarth GS. The BB diabetic rat. Profound T-cell lymphocytopenia. Diabetes. 1981 Oct;30(10):887–9.
Jackson, R., et al. “The BB diabetic rat. Profound T-cell lymphocytopenia.Diabetes, vol. 30, no. 10, Oct. 1981, pp. 887–89. Pubmed, doi:10.2337/diab.30.10.887.
Jackson R, Rassi N, Crump T, Haynes B, Eisenbarth GS. The BB diabetic rat. Profound T-cell lymphocytopenia. Diabetes. 1981 Oct;30(10):887–889.

Published In

Diabetes

DOI

ISSN

0012-1797

Publication Date

October 1981

Volume

30

Issue

10

Start / End Page

887 / 889

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Rats, Inbred Strains
  • Rats
  • Male
  • Lymphocyte Depletion
  • Leukocyte Count
  • Female
  • Endocrinology & Metabolism
  • Diabetes Mellitus
  • B-Lymphocytes