Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity.
Published
Journal Article
Antibody capacity to recognize infectious virus is a prerequisite of many antiviral functions. We determined the infectious virion capture index (IVCI) of different antibody specificities. Whereas broadly neutralizing antibodies (bNAbs), except for an MPER bNAb, selectively captured infectious virions, non-bNAbs and mucosal human immunodeficiency virus type 1 (HIV-1)-positive IgG captured subsets of both infectious and noninfectious virions. Infectious virion capture was additive with a mixture of antibodies, providing proof of concept for vaccine-induced antibodies that together have improved capacity to recognize infectious virions.
Full Text
Duke Authors
- Bonsignori, Mattia
- Haynes, Barton Ford
- Liao, Hua-Xin
- Moody, Michael Anthony
- Shen, Xiaoying
- Tomaras, Georgia Doris
Cited Authors
- Liu, P; Williams, LD; Shen, X; Bonsignori, M; Vandergrift, NA; Overman, RG; Moody, MA; Liao, H-X; Stieh, DJ; McCotter, KL; French, AL; Hope, TJ; Shattock, R; Haynes, BF; Tomaras, GD
Published Date
- May 2014
Published In
Volume / Issue
- 88 / 9
Start / End Page
- 5165 - 5170
PubMed ID
- 24554654
Pubmed Central ID
- 24554654
Electronic International Standard Serial Number (EISSN)
- 1098-5514
International Standard Serial Number (ISSN)
- 0022-538X
Digital Object Identifier (DOI)
- 10.1128/JVI.03765-13
Language
- eng