Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity.

Journal Article (Journal Article)

Antibody capacity to recognize infectious virus is a prerequisite of many antiviral functions. We determined the infectious virion capture index (IVCI) of different antibody specificities. Whereas broadly neutralizing antibodies (bNAbs), except for an MPER bNAb, selectively captured infectious virions, non-bNAbs and mucosal human immunodeficiency virus type 1 (HIV-1)-positive IgG captured subsets of both infectious and noninfectious virions. Infectious virion capture was additive with a mixture of antibodies, providing proof of concept for vaccine-induced antibodies that together have improved capacity to recognize infectious virions.

Full Text

Duke Authors

Cited Authors

  • Liu, P; Williams, LD; Shen, X; Bonsignori, M; Vandergrift, NA; Overman, RG; Moody, MA; Liao, H-X; Stieh, DJ; McCotter, KL; French, AL; Hope, TJ; Shattock, R; Haynes, BF; Tomaras, GD

Published Date

  • May 2014

Published In

Volume / Issue

  • 88 / 9

Start / End Page

  • 5165 - 5170

PubMed ID

  • 24554654

Pubmed Central ID

  • PMC3993833

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

Digital Object Identifier (DOI)

  • 10.1128/JVI.03765-13

Language

  • eng

Conference Location

  • United States