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Genetic determinants of renal transplant outcome: where do we stand?

Publication ,  Journal Article
Phelan, PJ; Conlon, PJ; Sparks, MA
Published in: J Nephrol
June 2014

Kidney transplantation has become the preferred method of renal replacement. However, the rate of long term allograft survival has not changed over the last decade. Donor and recipient genetic interplay influences kidney transplant outcome but our knowledge of these complex interactions is limited. Until recently, investigations have been limited to small candidate gene studies, usually restricted to allograft recipients. Genome-wide association studies have been slow to emerge in transplantation but the first has recently been reported and will be reviewed here. Much larger studies involving donor and recipients pairs are ongoing. We are now entering the era of epigenetics and whole genome sequencing which will hopefully provide a more in-depth knowledge of the genetic influences on renal transplant outcome. This may lead to a more accurate assessment of post-transplant risk, potentially allowing for the development of risk predication models leading to a more personalized approach to kidney transplant care. In this article, we examine the current and emerging literature in the field and discuss the limitations of current studies and technologies.

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Published In

J Nephrol

DOI

EISSN

1724-6059

Publication Date

June 2014

Volume

27

Issue

3

Start / End Page

247 / 256

Location

Italy

Related Subject Headings

  • Urology & Nephrology
  • Treatment Outcome
  • Tissue Donors
  • Risk Factors
  • Risk Assessment
  • Precision Medicine
  • Phenotype
  • Patient Selection
  • Kidney Transplantation
  • Kidney Diseases
 

Citation

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Phelan, P. J., Conlon, P. J., & Sparks, M. A. (2014). Genetic determinants of renal transplant outcome: where do we stand? J Nephrol, 27(3), 247–256. https://doi.org/10.1007/s40620-014-0053-4
Phelan, Paul J., Peter J. Conlon, and Matthew A. Sparks. “Genetic determinants of renal transplant outcome: where do we stand?J Nephrol 27, no. 3 (June 2014): 247–56. https://doi.org/10.1007/s40620-014-0053-4.
Phelan PJ, Conlon PJ, Sparks MA. Genetic determinants of renal transplant outcome: where do we stand? J Nephrol. 2014 Jun;27(3):247–56.
Phelan, Paul J., et al. “Genetic determinants of renal transplant outcome: where do we stand?J Nephrol, vol. 27, no. 3, June 2014, pp. 247–56. Pubmed, doi:10.1007/s40620-014-0053-4.
Phelan PJ, Conlon PJ, Sparks MA. Genetic determinants of renal transplant outcome: where do we stand? J Nephrol. 2014 Jun;27(3):247–256.
Journal cover image

Published In

J Nephrol

DOI

EISSN

1724-6059

Publication Date

June 2014

Volume

27

Issue

3

Start / End Page

247 / 256

Location

Italy

Related Subject Headings

  • Urology & Nephrology
  • Treatment Outcome
  • Tissue Donors
  • Risk Factors
  • Risk Assessment
  • Precision Medicine
  • Phenotype
  • Patient Selection
  • Kidney Transplantation
  • Kidney Diseases