Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis.
Published
Journal Article
Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.
Full Text
Duke Authors
Cited Authors
- Younes, L; Ratnanather, JT; Brown, T; Aylward, E; Nopoulos, P; Johnson, H; Magnotta, VA; Paulsen, JS; Margolis, RL; Albin, RL; Miller, MI; Ross, CA; PREDICT-HD Investigators and Coordinators of the Huntington Study Group,
Published Date
- March 2014
Published In
Volume / Issue
- 35 / 3
Start / End Page
- 792 - 809
PubMed ID
- 23281100
Pubmed Central ID
- 23281100
Electronic International Standard Serial Number (EISSN)
- 1097-0193
Digital Object Identifier (DOI)
- 10.1002/hbm.22214
Language
- eng
Conference Location
- United States