Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis.

Journal Article (Journal Article)

Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.

Full Text

Duke Authors

Cited Authors

  • Younes, L; Ratnanather, JT; Brown, T; Aylward, E; Nopoulos, P; Johnson, H; Magnotta, VA; Paulsen, JS; Margolis, RL; Albin, RL; Miller, MI; Ross, CA; PREDICT-HD Investigators and Coordinators of the Huntington Study Group,

Published Date

  • March 2014

Published In

Volume / Issue

  • 35 / 3

Start / End Page

  • 792 - 809

PubMed ID

  • 23281100

Pubmed Central ID

  • PMC3715588

Electronic International Standard Serial Number (EISSN)

  • 1097-0193

Digital Object Identifier (DOI)

  • 10.1002/hbm.22214


  • eng

Conference Location

  • United States