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Mortality and morbidity of VLBW infants with trisomy 13 or trisomy 18.

Publication ,  Journal Article
Boghossian, NS; Hansen, NI; Bell, EF; Stoll, BJ; Murray, JC; Carey, JC; Adams-Chapman, I; Shankaran, S; Walsh, MC; Laptook, AR; Faix, RG ...
Published in: Pediatrics
February 2014

OBJECTIVE: Little is known about how very low birth weight (VLBW) affects survival and morbidities among infants with trisomy 13 (T13) or trisomy 18 (T18). We examined the care plans for VLBW infants with T13 or T18 and compared their risks of mortality and neonatal morbidities with VLBW infants with trisomy 21 and VLBW infants without birth defects. METHODS: Infants with birth weight 401 to 1500 g born or cared for at a participating center of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network during the period 1994-2009 were studied. Poisson regression models were used to examine risk of death and neonatal morbidities among infants with T13 or T18. RESULTS: Of 52,262 VLBW infants, 38 (0.07%) had T13 and 128 (0.24%) had T18. Intensity of care in the delivery room varied depending on whether the trisomy was diagnosed before or after birth. The plan for subsequent care for the majority of the infants was to withdraw care or to provide comfort care. Eleven percent of infants with T13 and 9% of infants with T18 survived to hospital discharge. Survivors with T13 or T18 had significantly increased risk of patent ductus arteriosus and respiratory distress syndrome compared with infants without birth defects. No infant with T13 or T18 developed necrotizing enterocolitis. CONCLUSIONS: In this cohort of liveborn VLBW infants with T13 or T18, the timing of trisomy diagnosis affected the plan for care, survival was poor, and death usually occurred early.

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Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

February 2014

Volume

133

Issue

2

Start / End Page

226 / 235

Location

United States

Related Subject Headings

  • Trisomy 18 Syndrome
  • Trisomy 13 Syndrome
  • Trisomy
  • Retrospective Studies
  • Pediatrics
  • Male
  • Infant, Very Low Birth Weight
  • Infant, Newborn
  • Humans
  • Female
 

Citation

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Boghossian, N. S., Hansen, N. I., Bell, E. F., Stoll, B. J., Murray, J. C., Carey, J. C., … Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, . (2014). Mortality and morbidity of VLBW infants with trisomy 13 or trisomy 18. Pediatrics, 133(2), 226–235. https://doi.org/10.1542/peds.2013-1702
Boghossian, Nansi S., Nellie I. Hansen, Edward F. Bell, Barbara J. Stoll, Jeffrey C. Murray, John C. Carey, Ira Adams-Chapman, et al. “Mortality and morbidity of VLBW infants with trisomy 13 or trisomy 18.Pediatrics 133, no. 2 (February 2014): 226–35. https://doi.org/10.1542/peds.2013-1702.
Boghossian NS, Hansen NI, Bell EF, Stoll BJ, Murray JC, Carey JC, et al. Mortality and morbidity of VLBW infants with trisomy 13 or trisomy 18. Pediatrics. 2014 Feb;133(2):226–35.
Boghossian, Nansi S., et al. “Mortality and morbidity of VLBW infants with trisomy 13 or trisomy 18.Pediatrics, vol. 133, no. 2, Feb. 2014, pp. 226–35. Pubmed, doi:10.1542/peds.2013-1702.
Boghossian NS, Hansen NI, Bell EF, Stoll BJ, Murray JC, Carey JC, Adams-Chapman I, Shankaran S, Walsh MC, Laptook AR, Faix RG, Newman NS, Hale EC, Das A, Wilson LD, Hensman AM, Grisby C, Collins MV, Vasil DM, Finkle J, Maffett D, Ball MB, Lacy CB, Bara R, Higgins RD, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Mortality and morbidity of VLBW infants with trisomy 13 or trisomy 18. Pediatrics. 2014 Feb;133(2):226–235.

Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

February 2014

Volume

133

Issue

2

Start / End Page

226 / 235

Location

United States

Related Subject Headings

  • Trisomy 18 Syndrome
  • Trisomy 13 Syndrome
  • Trisomy
  • Retrospective Studies
  • Pediatrics
  • Male
  • Infant, Very Low Birth Weight
  • Infant, Newborn
  • Humans
  • Female