Material characterization of in vivo and in vitro porcine brain using shear wave elasticity
Shear wave elasticity imaging was used to examine changes in porcine brain tissue shear modulus as a function of several experimental and physiological parameters. Animal studies were performed with two different ultrasound transducers. Four in vivo subjects were exposed to inversion and increased ICP, over a relevant physiological range (0-40mmHg), was correlated with shear wave speed estimates. Additional in vitro specimens were used to investigate presence of changes with temperature, confinement, spatial location, and transducer orientation. Statistically significant results include a 28% decrease in stiffness with increased temperature and a 22-50% increase in stiffness with decreasing external confinement. © 2013 IEEE.
Urbanczyk, C; Palmeri, M; Bass, CR
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