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Gastroesophageal heterotopia and HER2/neu overexpression in an adenocarcinoma arising from a small bowel duplication.

Publication ,  Journal Article
Nussbaum, DP; Bhattacharya, SD; Jiang, X; Cardona, DM; Strickler, JH; Blazer, DG
Published in: Arch Pathol Lab Med
March 2014

Small bowel duplications are congenital structures commonly lined by heterotopic gastric or pancreatic mucosa. Though benign in children, small bowel duplications have the potential for malignant degeneration in adulthood. Here, we present the first reported case of metastatic adenocarcinoma arising from a small bowel duplication lined by gastroesophageal mucosa. The cancer demonstrated overexpression of the HER2/neu oncoprotein and amplification of the HER2/neu gene. This represents the only report of HER2 overexpression in this type of lesion. The patient is being treated with traditional chemotherapeutic agents in addition to monoclonal antibody therapy directed at the HER2 protein, and has demonstrated a clinical benefit from treatment. This case demonstrates that the anatomic location of a mass may be distinct from its biological origin, and this difference may have important practical implications for diagnostic testing and treatment.

Duke Scholars

Published In

Arch Pathol Lab Med

DOI

EISSN

1543-2165

Publication Date

March 2014

Volume

138

Issue

3

Start / End Page

428 / 431

Location

United States

Related Subject Headings

  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Pathology
  • Middle Aged
  • Male
  • Intestine, Small
  • Intestinal Neoplasms
  • Humans
  • Gastric Mucosa
  • Choristoma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nussbaum, D. P., Bhattacharya, S. D., Jiang, X., Cardona, D. M., Strickler, J. H., & Blazer, D. G. (2014). Gastroesophageal heterotopia and HER2/neu overexpression in an adenocarcinoma arising from a small bowel duplication. Arch Pathol Lab Med, 138(3), 428–431. https://doi.org/10.5858/arpa.2012-0523-CR
Nussbaum, Daniel P., Syamal D. Bhattacharya, Xiaoyin Jiang, Diana M. Cardona, John H. Strickler, and Dan G. Blazer. “Gastroesophageal heterotopia and HER2/neu overexpression in an adenocarcinoma arising from a small bowel duplication.Arch Pathol Lab Med 138, no. 3 (March 2014): 428–31. https://doi.org/10.5858/arpa.2012-0523-CR.
Nussbaum DP, Bhattacharya SD, Jiang X, Cardona DM, Strickler JH, Blazer DG. Gastroesophageal heterotopia and HER2/neu overexpression in an adenocarcinoma arising from a small bowel duplication. Arch Pathol Lab Med. 2014 Mar;138(3):428–31.
Nussbaum, Daniel P., et al. “Gastroesophageal heterotopia and HER2/neu overexpression in an adenocarcinoma arising from a small bowel duplication.Arch Pathol Lab Med, vol. 138, no. 3, Mar. 2014, pp. 428–31. Pubmed, doi:10.5858/arpa.2012-0523-CR.
Nussbaum DP, Bhattacharya SD, Jiang X, Cardona DM, Strickler JH, Blazer DG. Gastroesophageal heterotopia and HER2/neu overexpression in an adenocarcinoma arising from a small bowel duplication. Arch Pathol Lab Med. 2014 Mar;138(3):428–431.

Published In

Arch Pathol Lab Med

DOI

EISSN

1543-2165

Publication Date

March 2014

Volume

138

Issue

3

Start / End Page

428 / 431

Location

United States

Related Subject Headings

  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Pathology
  • Middle Aged
  • Male
  • Intestine, Small
  • Intestinal Neoplasms
  • Humans
  • Gastric Mucosa
  • Choristoma