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Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.

Publication ,  Journal Article
Cornejo-García, JA; Liou, L-B; Blanca-López, N; Doña, I; Chen, C-H; Chou, Y-C; Chuang, H-P; Wu, J-Y; Chen, Y-T; Plaza-Serón, MDC; Mayorga, C ...
Published in: Pharmacogenomics
November 2013

AIM: Acute urticaria/angioedema (AUA) induced by cross-intolerance to NSAIDs is the most frequent clinical entity in hypersensitivity reactions to drugs. In this work, we conducted a genome-wide association study in Spanish and Han Chinese patients suffering from NSAID-induced AUA. MATERIALS & METHODS: A whole-genome scan was performed on a total of 232 cases (112 Spanish and 120 Han Chinese) with NSAID-induced AUA and 225 unrelated controls (124 Spanish and 101 Han Chinese). RESULTS: Although no polymorphism reached genome-wide significance, we obtained suggestive associations for three clusters in the Spanish group (RIMS1, BICC1 and RAD51L 1) and one region in the Han Chinese population (ABI3BP). Five regions showed suggestive associations after meta-analysis: HLF, RAD51L1, COL24A1, GalNAc-T13 and FBXL7. A majority of these genes are related to Ca(2+), cAMP and/or P53 signaling pathways. CONCLUSION: The associations described were different from those related to the metabolism of arachidonic acid and could provide new mechanisms underlying NSAID-induced AUA.

Duke Scholars

Published In

Pharmacogenomics

DOI

EISSN

1744-8042

Publication Date

November 2013

Volume

14

Issue

15

Start / End Page

1857 / 1869

Location

England

Related Subject Headings

  • Urticaria
  • Tumor Suppressor Protein p53
  • Pharmacology & Pharmacy
  • Middle Aged
  • Male
  • Humans
  • Hispanic or Latino
  • Genotype
  • Genome-Wide Association Study
  • Female
 

Citation

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Cornejo-García, J. A., Liou, L.-B., Blanca-López, N., Doña, I., Chen, C.-H., Chou, Y.-C., … Lee, M. T. M. (2013). Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations. Pharmacogenomics, 14(15), 1857–1869. https://doi.org/10.2217/pgs.13.166
Cornejo-García, José Antonio, Lieh-Bang Liou, Natalia Blanca-López, Inmaculada Doña, Chien-Hsiun Chen, Yi-Chun Chou, Hui-Ping Chuang, et al. “Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.Pharmacogenomics 14, no. 15 (November 2013): 1857–69. https://doi.org/10.2217/pgs.13.166.
Cornejo-García JA, Liou L-B, Blanca-López N, Doña I, Chen C-H, Chou Y-C, et al. Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations. Pharmacogenomics. 2013 Nov;14(15):1857–69.
Cornejo-García, José Antonio, et al. “Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.Pharmacogenomics, vol. 14, no. 15, Nov. 2013, pp. 1857–69. Pubmed, doi:10.2217/pgs.13.166.
Cornejo-García JA, Liou L-B, Blanca-López N, Doña I, Chen C-H, Chou Y-C, Chuang H-P, Wu J-Y, Chen Y-T, Plaza-Serón MDC, Mayorga C, Guéant-Rodríguez RM, Lin S-C, Torres MJ, Campo P, Rondón C, Laguna JJ, Fernández J, Guéant J-L, Canto G, Blanca M, Lee MTM. Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations. Pharmacogenomics. 2013 Nov;14(15):1857–1869.
Journal cover image

Published In

Pharmacogenomics

DOI

EISSN

1744-8042

Publication Date

November 2013

Volume

14

Issue

15

Start / End Page

1857 / 1869

Location

England

Related Subject Headings

  • Urticaria
  • Tumor Suppressor Protein p53
  • Pharmacology & Pharmacy
  • Middle Aged
  • Male
  • Humans
  • Hispanic or Latino
  • Genotype
  • Genome-Wide Association Study
  • Female