Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.


Journal Article

AIM: Acute urticaria/angioedema (AUA) induced by cross-intolerance to NSAIDs is the most frequent clinical entity in hypersensitivity reactions to drugs. In this work, we conducted a genome-wide association study in Spanish and Han Chinese patients suffering from NSAID-induced AUA. MATERIALS & METHODS: A whole-genome scan was performed on a total of 232 cases (112 Spanish and 120 Han Chinese) with NSAID-induced AUA and 225 unrelated controls (124 Spanish and 101 Han Chinese). RESULTS: Although no polymorphism reached genome-wide significance, we obtained suggestive associations for three clusters in the Spanish group (RIMS1, BICC1 and RAD51L 1) and one region in the Han Chinese population (ABI3BP). Five regions showed suggestive associations after meta-analysis: HLF, RAD51L1, COL24A1, GalNAc-T13 and FBXL7. A majority of these genes are related to Ca(2+), cAMP and/or P53 signaling pathways. CONCLUSION: The associations described were different from those related to the metabolism of arachidonic acid and could provide new mechanisms underlying NSAID-induced AUA.

Full Text

Duke Authors

Cited Authors

  • Cornejo-García, JA; Liou, L-B; Blanca-López, N; Doña, I; Chen, C-H; Chou, Y-C; Chuang, H-P; Wu, J-Y; Chen, Y-T; Plaza-Serón, MDC; Mayorga, C; Guéant-Rodríguez, RM; Lin, S-C; Torres, MJ; Campo, P; Rondón, C; Laguna, JJ; Fernández, J; Guéant, J-L; Canto, G; Blanca, M; Lee, MTM

Published Date

  • November 2013

Published In

Volume / Issue

  • 14 / 15

Start / End Page

  • 1857 - 1869

PubMed ID

  • 24236485

Pubmed Central ID

  • 24236485

Electronic International Standard Serial Number (EISSN)

  • 1744-8042

Digital Object Identifier (DOI)

  • 10.2217/pgs.13.166


  • eng

Conference Location

  • England