Prioritization of research addressing antipsychotics for adolescents and young adults with bipolar disorder.
Journal Article (Journal Article)
Despite a paucity of high-quality evidence about benefits and harms, antipsychotic medication use among adolescents and young adults with bipolar disorder is increasing. The Patient-Centered Outcomes Research Institute tasked the Duke Evidence Synthesis Group with creating a prioritized agenda for research in this area that would incorporate the perspectives of relevant stakeholders. We identified a list of potential evidence gaps by reviewing existing literature and engaged a diverse group of 9 stakeholders to expand and refine this list. Using a forced-ranking prioritization method, stakeholders prioritized 10 of 23 potential evidence gaps as the most pressing for future research. These evidence gaps relate to 3 areas: the comparative effectiveness of intervention strategies, the effect of antipsychotics on patient-centered outcomes, and the influence of various patient characteristics on antipsychotic effectiveness. In addition to presenting these findings, we suggest appropriate study designs for addressing the stakeholder-prioritized research questions.
Full Text
Duke Authors
- Chatterjee, Ranee
- Coeytaux, Remy Rene
- Crowley, Matthew Janik
- Gierisch, Jennifer M.
- McCrory, Douglas Charles
- Myers, Evan Robert
- Schmidler, Gillian Denise Sanders
Cited Authors
- Crowley, MJ; McCrory, DC; Chatterjee, R; Gierisch, JM; Myers, ER; Schmit, KM; Coeytaux, RR; Correll, CU; Kendrick, AS; Sanders, GD
Published Date
- April 1, 2014
Published In
Volume / Issue
- 160 / 7
Start / End Page
- 492 - 498
PubMed ID
- 24567115
Electronic International Standard Serial Number (EISSN)
- 1539-3704
Digital Object Identifier (DOI)
- 10.7326/M13-2549
Language
- eng
Conference Location
- United States