Prioritization of research addressing antipsychotics for adolescents and young adults with bipolar disorder.

Journal Article (Journal Article)

Despite a paucity of high-quality evidence about benefits and harms, antipsychotic medication use among adolescents and young adults with bipolar disorder is increasing. The Patient-Centered Outcomes Research Institute tasked the Duke Evidence Synthesis Group with creating a prioritized agenda for research in this area that would incorporate the perspectives of relevant stakeholders. We identified a list of potential evidence gaps by reviewing existing literature and engaged a diverse group of 9 stakeholders to expand and refine this list. Using a forced-ranking prioritization method, stakeholders prioritized 10 of 23 potential evidence gaps as the most pressing for future research. These evidence gaps relate to 3 areas: the comparative effectiveness of intervention strategies, the effect of antipsychotics on patient-centered outcomes, and the influence of various patient characteristics on antipsychotic effectiveness. In addition to presenting these findings, we suggest appropriate study designs for addressing the stakeholder-prioritized research questions.

Full Text

Duke Authors

Cited Authors

  • Crowley, MJ; McCrory, DC; Chatterjee, R; Gierisch, JM; Myers, ER; Schmit, KM; Coeytaux, RR; Correll, CU; Kendrick, AS; Sanders, GD

Published Date

  • April 1, 2014

Published In

Volume / Issue

  • 160 / 7

Start / End Page

  • 492 - 498

PubMed ID

  • 24567115

Electronic International Standard Serial Number (EISSN)

  • 1539-3704

Digital Object Identifier (DOI)

  • 10.7326/M13-2549


  • eng

Conference Location

  • United States