Merkel cell carcinoma with partial B-cell blastic immunophenotype: a potential mimic of cutaneous richter transformation in a patient with chronic lymphocytic lymphoma.

Journal Article (Journal Article)

Merkel cell polyomavirus (MCPyV) is a DNA virus whose pathogenic mechanisms in Merkel cell carcinoma (MCC) are still being unraveled. Emerging reports of an association between MCPyV and chronic lymphocytic lymphoma (CLL) have begun to broaden our understanding of the oncogenic mechanisms of this virus and the known association between these 2 malignancies. Herein, we report a case of MCC demonstrating a B-cell immunophenotype arising in a patient with CLL being treated with rituximab. In this context, we discuss the differential diagnostic considerations, especially with cutaneous Richter transformation (diffuse large B-cell lymphoma). We also assessed for the presence of MCPyV in both the patient's MCC and the CLL. Finally, we provide a large meta-analysis of patients with CLL and MCC. Patients with both MCC and CLL have a dismal prognosis, with greater than 50% overall mortality within the first year and a half after MCC diagnosis.

Full Text

Duke Authors

Cited Authors

  • Papalas, JA; McKinney, MS; Kulbacki, E; Dave, SS; Wang, E

Published Date

  • February 2014

Published In

Volume / Issue

  • 36 / 2

Start / End Page

  • 148 - 152

PubMed ID

  • 24556900

Pubmed Central ID

  • PMC3931981

Electronic International Standard Serial Number (EISSN)

  • 1533-0311

Digital Object Identifier (DOI)

  • 10.1097/DAD.0b013e31829ed784


  • eng

Conference Location

  • United States