The superior longitudinal fasciculus in typically developing children and adolescents: diffusion tensor imaging and neuropsychological correlates.

Journal Article (Journal Article)

The relationship between superior longitudinal fasciculus microstructural integrity and neuropsychological functions were examined in 49 healthy children (range: 5-17 years) using diffusion tensor imaging. Seven major cognitive domains (intelligence, fine-motor, attention, language, visual-spatial, memory, executive function) were assessed. Data analyses used correlational methods. After adjusting for age and gender, fractional anisotropy and axial diffusivity values in the superior longitudinal fasciculus were positively correlated with executive functions of set shifting, whereas left superior longitudinal fasciculus fractional anisotropy values correlated with attention and language. Apparent diffusion coefficient values in the left superior longitudinal fasciculus negatively correlated with inhibitory control. In the left arcuate fasciculus, fractional anisotropy correlated with IQ and attention, whereas radial diffusivity values negatively correlated with IQ, fine-motor skills, and expressive language. Findings from this study provide an examination of the relationship between superior longitudinal fasciculus integrity and children's neuropsychological abilities that can be useful in monitoring pediatric neurologic diseases.

Full Text

Duke Authors

Cited Authors

  • Urger, SE; De Bellis, MD; Hooper, SR; Woolley, DP; Chen, SD; Provenzale, J

Published Date

  • January 2015

Published In

Volume / Issue

  • 30 / 1

Start / End Page

  • 9 - 20

PubMed ID

  • 24556549

Pubmed Central ID

  • PMC4138302

Electronic International Standard Serial Number (EISSN)

  • 1708-8283

Digital Object Identifier (DOI)

  • 10.1177/0883073813520503


  • eng

Conference Location

  • United States