Impact of delivery models on understanding genomic risk for type 2 diabetes.

Journal Article (Journal Article)

BACKGROUND: Genetic information, typically communicated in-person by genetic counselors, can be challenging to comprehend; delivery of this information online--as is becoming more common--has the potential of increasing these challenges. METHODS: To address the impact of the mode of delivery of genomic risk information, 300 individuals were recruited from the general public and randomized to receive genomic risk information for type 2 diabetes mellitus in-person from a board-certified genetic counselor or online through the testing company's website. RESULTS: Participants were asked to indicate their genomic risk and overall lifetime risk as reported on their test report as well as to interpret their genomic risk (increased, decreased, or same as population). For each question, 59% of participants correctly indicated their risk. Participants who received their results in-person were more likely than those who reviewed their results on-line to correctly interpret their genomic risk (72 vs. 47%, p = 0.0002) and report their actual genomic risk (69 vs. 49%, p = 0.002). CONCLUSIONS: The delivery of personal genomic risk through a trained health professional resulted in significantly higher comprehension. Therefore, if the online delivery of genomic test results is to become more widespread, further evaluation of this method of communication may be needed to ensure the effective presentation of results to promote comprehension.

Full Text

Duke Authors

Cited Authors

  • Haga, SB; Barry, WT; Mills, R; Svetkey, L; Suchindran, S; Willard, HF; Ginsburg, GS

Published Date

  • 2014

Published In

Volume / Issue

  • 17 / 2

Start / End Page

  • 95 - 104

PubMed ID

  • 24577154

Pubmed Central ID

  • PMC4028057

Electronic International Standard Serial Number (EISSN)

  • 1662-8063

Digital Object Identifier (DOI)

  • 10.1159/000358413


  • eng

Conference Location

  • Switzerland