Mast cell mediator responses and their suppression by pathogenic and commensal microorganisms.

Journal Article (Journal Article;Review)

Mast cells (MCs) are selectively found at the host environment interface and are capable of secreting a wide array of pharmacologically active mediators, many of which are prepackaged in granules. Over the past two decades, it has become clear that these cells have the capacity to recognize a range of infectious agents allowing them to play a key role in initiating and modulating early immune responses to infectious agents. However, a number of pathogenic and commensal microbes appear to have evolved distinct mechanisms to suppress MC mediator release to avoid elimination in the host. Understanding how these microbes suppress MC functions may have significant therapeutic value to relieve inflammatory disorders mediated by MCs.

Full Text

Duke Authors

Cited Authors

  • Choi, HW; Abraham, SN

Published Date

  • January 2015

Published In

Volume / Issue

  • 63 / 1

Start / End Page

  • 74 - 79

PubMed ID

  • 24636146

Pubmed Central ID

  • PMC4326045

Electronic International Standard Serial Number (EISSN)

  • 1872-9142

Digital Object Identifier (DOI)

  • 10.1016/j.molimm.2014.02.006


  • eng

Conference Location

  • England