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ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma.

Publication ,  Journal Article
Nongpiur, ME; Khor, CC; Jia, H; Cornes, BK; Chen, L-J; Qiao, C; Nair, KS; Cheng, C-Y; Xu, L; George, R; Tan, D; Abu-Amero, K; Perera, SA ...
Published in: PLoS Genet
March 2014

Anterior chamber depth (ACD) is a key anatomical risk factor for primary angle closure glaucoma (PACG). We conducted a genome-wide association study (GWAS) on ACD to discover novel genes for PACG on a total of 5,308 population-based individuals of Asian descent. Genome-wide significant association was observed at a sequence variant within ABCC5 (rs1401999; per-allele effect size =  -0.045 mm, P = 8.17 × 10(-9)). This locus was associated with an increase in risk of PACG in a separate case-control study of 4,276 PACG cases and 18,801 controls (per-allele OR = 1.13 [95% CI: 1.06-1.22], P = 0.00046). The association was strengthened when a sub-group of controls with open angles were included in the analysis (per-allele OR = 1.30, P = 7.45 × 10(-9); 3,458 cases vs. 3,831 controls). Our findings suggest that the increase in PACG risk could in part be mediated by genetic sequence variants influencing anterior chamber dimensions.

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Published In

PLoS Genet

DOI

EISSN

1553-7404

Publication Date

March 2014

Volume

10

Issue

3

Start / End Page

e1004089

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Multidrug Resistance-Associated Proteins
  • Humans
  • Glaucoma, Angle-Closure
  • Genome-Wide Association Study
  • Developmental Biology
  • Asian People
  • Anterior Chamber
  • 3105 Genetics
 

Citation

APA
Chicago
ICMJE
MLA
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Nongpiur, M. E., Khor, C. C., Jia, H., Cornes, B. K., Chen, L.-J., Qiao, C., … Aung, T. (2014). ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma. PLoS Genet, 10(3), e1004089. https://doi.org/10.1371/journal.pgen.1004089
Nongpiur, Monisha E., Chiea Chuen Khor, Hongyan Jia, Belinda K. Cornes, Li-Jia Chen, Chunyan Qiao, K Saidas Nair, et al. “ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma.PLoS Genet 10, no. 3 (March 2014): e1004089. https://doi.org/10.1371/journal.pgen.1004089.
Nongpiur ME, Khor CC, Jia H, Cornes BK, Chen L-J, Qiao C, et al. ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma. PLoS Genet. 2014 Mar;10(3):e1004089.
Nongpiur, Monisha E., et al. “ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma.PLoS Genet, vol. 10, no. 3, Mar. 2014, p. e1004089. Pubmed, doi:10.1371/journal.pgen.1004089.
Nongpiur ME, Khor CC, Jia H, Cornes BK, Chen L-J, Qiao C, Nair KS, Cheng C-Y, Xu L, George R, Tan D, Abu-Amero K, Perera SA, Ozaki M, Mizoguchi T, Kurimoto Y, Low S, Tajudin L-SA, Ho C-L, Tham CCY, Soto I, Chew PTK, Wong H-T, Shantha B, Kuroda M, Osman EA, Tang G, Fan S, Meng H, Wang H, Feng B, Yong VHK, Ting SML, Li Y, Wang Y-X, Li Z, Lavanya R, Wu R-Y, Zheng Y-F, Su DH, Loon S-C, Yong VKY, Allingham RR, Hauser MA, Soumittra N, Ramprasad VL, Waseem N, Yaakub A, Chia K-S, Kumaramanickavel G, Wong TT, How AC, Chau TNB, Simmons CP, Bei J-X, Zeng Y-X, Bhattacharya SS, Zhang M, Tan DT, Teo Y-Y, Al-Obeidan SA, Hon DN, Tai E-S, Saw S-M, Foster PJ, Vijaya L, Jonas JB, Wong T-Y, John SWM, Pang C-P, Vithana EN, Wang N, Aung T. ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma. PLoS Genet. 2014 Mar;10(3):e1004089.

Published In

PLoS Genet

DOI

EISSN

1553-7404

Publication Date

March 2014

Volume

10

Issue

3

Start / End Page

e1004089

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Multidrug Resistance-Associated Proteins
  • Humans
  • Glaucoma, Angle-Closure
  • Genome-Wide Association Study
  • Developmental Biology
  • Asian People
  • Anterior Chamber
  • 3105 Genetics