Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET).
Journal Article (Journal Article;Multicenter Study)
BACKGROUND: Invasive fungal infections are a major cause of morbidity and mortality among solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients, but few data have been reported on the epidemiology of endemic fungal infections in these populations. METHODS: Fifteen institutions belonging to the Transplant-Associated Infection Surveillance Network prospectively enrolled SOT and HCT recipients with histoplasmosis, blastomycosis, or coccidioidomycosis occurring between March 2001 and March 2006. RESULTS: A total of 70 patients (64 SOT recipients and 6 HCT recipients) had infection with an endemic mycosis, including 52 with histoplasmosis, 9 with blastomycosis, and 9 with coccidioidomycosis. The 12-month cumulative incidence rate among SOT recipients for histoplasmosis was 0.102%. Occurrence of infection was bimodal; 28 (40%) infections occurred in the first 6 months post transplantation, and 24 (34%) occurred between 2 and 11 years post transplantation. Three patients were documented to have acquired infection from the donor organ. Seven SOT recipients with histoplasmosis and 3 with coccidioidomycosis died (16%); no HCT recipient died. CONCLUSIONS: This 5-year multicenter prospective surveillance study found that endemic mycoses occur uncommonly in SOT and HCT recipients, and that the period at risk extends for years after transplantation.
Full Text
Duke Authors
Cited Authors
- Kauffman, CA; Freifeld, AG; Andes, DR; Baddley, JW; Herwaldt, L; Walker, RC; Alexander, BD; Anaissie, EJ; Benedict, K; Ito, JI; Knapp, KM; Lyon, GM; Marr, KA; Morrison, VA; Park, BJ; Patterson, TF; Schuster, MG; Chiller, TM; Pappas, PG
Published Date
- April 2014
Published In
Volume / Issue
- 16 / 2
Start / End Page
- 213 - 224
PubMed ID
- 24589027
Pubmed Central ID
- PMC5664161
Electronic International Standard Serial Number (EISSN)
- 1399-3062
Digital Object Identifier (DOI)
- 10.1111/tid.12186
Language
- eng
Conference Location
- Denmark