Estimation of shear wave speed in the human uterine cervix.

Journal Article

To explore spatial variability within the cervix and the sensitivity of shear wave speed (SWS) to assess softness/stiffness differences in ripened (softened) vs unripened tissue.We obtained SWS estimates from hysterectomy specimens (n = 22), a subset of which were ripened (n = 13). Multiple measurements were made longitudinally along the cervical canal on both the anterior and posterior sides of the cervix. Statistical tests of differences in the proximal vs distal, anterior vs posterior and ripened vs unripened cervix were performed with individual two-sample t-tests and a linear mixed model.Estimates of SWS increase monotonically from distal to proximal longitudinally along the cervix, they vary in the anterior compared to the posterior cervix and they are significantly different in ripened vs unripened cervical tissue. Specifically, the mid position SWS estimates for the unripened group were 3.45 ± 0.95 m/s (anterior; mean ± SD) and 3.56 ± 0.92 m/s (posterior), and 2.11 ± 0.45 m/s (anterior) and 2.68 ± 0.57 m/s (posterior) for the ripened group (P < 0.001).We propose that SWS estimation may be a valuable research and, ultimately, diagnostic tool for objective quantification of cervical stiffness/softness.

Full Text

Duke Authors

Cited Authors

  • Carlson, LC; Feltovich, H; Palmeri, ML; Dahl, JJ; Munoz del Rio, A; Hall, TJ

Published Date

  • April 2014

Published In

Volume / Issue

  • 43 / 4

Start / End Page

  • 452 - 458

PubMed ID

  • 23836486

Electronic International Standard Serial Number (EISSN)

  • 1469-0705

International Standard Serial Number (ISSN)

  • 0960-7692

Digital Object Identifier (DOI)

  • 10.1002/uog.12555

Language

  • eng