Weight changes in obese adults 6-months after discontinuation of double-blind zonisamide or placebo treatment.

Published

Journal Article

We evaluated weight changes in obese patients at 6-months after they ended participation in a 12-month randomised controlled trial in which they received daily placebo, zonisamide 200 mg or zonisamide 400 mg, in addition to lifestyle counselling. Of the originally randomised 225 patients, 218 completed month-12 when study interventions were discontinued. For the 154 patients who returned for 6-month follow-up off-treatment, weight changes between month-12 and month-18 for placebo (n = 53), zonisamide 200 mg (n = 49) and zonisamide 400 mg groups (n = 52) were 0.5 kg [95% confidence interval (CI), -0.8 to 1.8; 0.7%], 1.5 kg (0.2-2.8; 1.6%; p = 0.26 vs. placebo) and 2.4 kg (1.1-3.7; 2.6%; p = 0.04 vs. placebo), respectively. Our results suggest that although zonisamide 400 mg daily for 12-months resulted in greater weight loss than with placebo, weight regain after discontinuation of interventions was greater in the zonisamide 400 mg group than placebo group.

Full Text

Duke Authors

Cited Authors

  • Shin, JH; Gadde, KM; Østbye, T; Bray, GA

Published Date

  • August 2014

Published In

Volume / Issue

  • 16 / 8

Start / End Page

  • 766 - 768

PubMed ID

  • 25123600

Pubmed Central ID

  • 25123600

Electronic International Standard Serial Number (EISSN)

  • 1463-1326

International Standard Serial Number (ISSN)

  • 1462-8902

Digital Object Identifier (DOI)

  • 10.1111/dom.12275

Language

  • eng