Interactions between micro- and macroparasites predict microparasite species richness across primates.
Journal Article (Journal Article)
Most wild animals face concurrent challenges by multiple infectious organisms, and immunological responses triggered by some parasites may increase susceptibility to other infectious agents. Immune-mediated interactions among parasites have been investigated among individuals in a population, but less is known about broader comparative patterns. We investigated the "macro-micro facilitation hypothesis" that higher helminth prevalence in a host species provides greater opportunities for intracellular parasites to invade, resulting in higher richness of intracellular microparasites. We obtained data on average helminth prevalence for 70 primate hosts, along with data on richness of intra- and extracellular infectious organisms. Using Bayesian phylogenetic methods, we found that primate species with higher overall helminth prevalence harbored more species of intracellular microparasites, while the positive association between helminth prevalence and extracellular microparasite species richness was weaker. The relationships held after controlling for potentially confounding variables, but associations were not found in focused tests of prevalence for six genera of well-studied helminths. The magnitude of support and effect sizes for overall helminth prevalence on intracellular microparasite species richness was similar to support for other well recognized ecological and life-history drivers of parasite species richness. Our findings therefore suggest that intrahost parasite interactions are as important as some ecological characteristics of hosts in accounting for parasite richness across host species.
Full Text
Duke Authors
Cited Authors
- Nunn, CL; Brezine, C; Jolles, AE; Ezenwa, VO
Published Date
- April 2014
Published In
Volume / Issue
- 183 / 4
Start / End Page
- 494 - 505
PubMed ID
- 24642494
Electronic International Standard Serial Number (EISSN)
- 1537-5323
International Standard Serial Number (ISSN)
- 0003-0147
Digital Object Identifier (DOI)
- 10.1086/675362
Language
- eng