Mitochondrial biogenesis: regulation by endogenous gases during inflammation and organ stress.

Published

Journal Article (Review)

The influence of mitochondrial dysfunction on pathological states involving inflammatory and/or oxidative stress in tissues that do not show frank cellular apoptosis or necrosis has been rather difficult to unravel, and the literature is replete with contradictory information. Although such discrepancies have many potential causes related to the type of injurious agent, the severity and duration of the injury, and the particular cells and tissues and the functions involved, it is the successful induction of cellular adaptive responses that ultimately governs the resolution of mitochondrial dysfunction and survival of the cell. Much recent attention has been devoted to unraveling the signaling pathways that activate mitochondrial biogenesis and other processes involved in mitochondrial quality control (QC) during inflammatory and oxidative stress with an eye towards the development of novel targets for therapeutic mitigation of the resultant tissue damage. This review provides a brief overview of this emerging field with an emphasis on the role of signaling through the endogenous gases (NO, CO and H2S) and a redox-based approach that brings transparency to key factors that contribute to the resolution of mitochondrial dysfunction and the maintenance of cell vitality. We make the case that targeted stimulation of mitochondrial biogenesis could be a potentially valuable approach for the development of new therapies for the treatment of diseases for which mitochondrial damage is a major consideration.

Full Text

Duke Authors

Cited Authors

  • Suliman, HB; Piantadosi, CA

Published Date

  • 2014

Published In

Volume / Issue

  • 20 / 35

Start / End Page

  • 5653 - 5662

PubMed ID

  • 24606800

Pubmed Central ID

  • 24606800

Electronic International Standard Serial Number (EISSN)

  • 1873-4286

Digital Object Identifier (DOI)

  • 10.2174/1381612820666140306095717

Language

  • eng

Conference Location

  • United Arab Emirates