Central nervous system cancers.

Journal Article (Journal Article)

Primary and metastatic tumors of the central nervous system are a heterogeneous group of neoplasms with varied outcomes and management strategies. Recently, improved survival observed in 2 randomized clinical trials established combined chemotherapy and radiation as the new standard for treating patients with pure or mixed anaplastic oligodendroglioma harboring the 1p/19q codeletion. For metastatic disease, increasing evidence supports the efficacy of stereotactic radiosurgery in treating patients with multiple metastatic lesions but low overall tumor volume. These guidelines provide recommendations on the diagnosis and management of this group of diseases based on clinical evidence and panel consensus. This version includes expert advice on the management of low-grade infiltrative astrocytomas, oligodendrogliomas, anaplastic gliomas, glioblastomas, medulloblastomas, supratentorial primitive neuroectodermal tumors, and brain metastases. The full online version, available at NCCN. org, contains recommendations on additional subtypes.

Full Text

Duke Authors

Cited Authors

  • Nabors, LB; Ammirati, M; Bierman, PJ; Brem, H; Butowski, N; Chamberlain, MC; DeAngelis, LM; Fenstermaker, RA; Friedman, A; Gilbert, MR; Hesser, D; Holdhoff, M; Junck, L; Lawson, R; Loeffler, JS; Maor, MH; Moots, PL; Morrison, T; Mrugala, MM; Newton, HB; Portnow, J; Raizer, JJ; Recht, L; Shrieve, DC; Sills, AK; Tran, D; Tran, N; Vrionis, FD; Wen, PY; McMillian, N; Ho, M; National Comprehensive Cancer Network,

Published Date

  • September 1, 2013

Published In

Volume / Issue

  • 11 / 9

Start / End Page

  • 1114 - 1151

PubMed ID

  • 24029126

Pubmed Central ID

  • PMC4124889

Electronic International Standard Serial Number (EISSN)

  • 1540-1413

Digital Object Identifier (DOI)

  • 10.6004/jnccn.2013.0132


  • eng

Conference Location

  • United States