The use of digoxin in patients with worsening chronic heart failure: reconsidering an old drug to reduce hospital admissions.

Published

Journal Article (Review)

Digoxin is the oldest cardiac drug still in contemporary use, yet its role in the management of patients with heart failure (HF) remains controversial. A purified cardiac glycoside derived from the foxglove plant, digoxin increases ejection fraction, augments cardiac output, and reduces pulmonary capillary wedge pressure without causing deleterious increases in heart rate or decreases in blood pressure. Moreover, it is also a neurohormonal modulator at low doses. In the pivotal DIG (Digitalis Investigation Group) trial, digoxin therapy was shown to reduce all-cause and HF-specific hospitalizations but had no effect on survival. With the discovery of neurohormonal blockers capable of reducing mortality in HF with reduced ejection fraction, the results of the DIG trial were viewed as neutral, and the use of digoxin declined precipitously. Although modern drug and device-based therapies have dramatically improved the survival of ambulatory patients with HF, outcomes for patients with worsening chronic HF, defined as deteriorating signs and symptoms on standard therapy often leading to unscheduled clinic or emergency department visits or hospitalization, have largely remained unchanged over the past 2 decades. The available data suggest that a therapeutic trial of digoxin may be appropriate in patients with worsening chronic heart failure who remain symptomatic.

Full Text

Cited Authors

  • Ambrosy, AP; Butler, J; Ahmed, A; Vaduganathan, M; van Veldhuisen, DJ; Colucci, WS; Gheorghiade, M

Published Date

  • May 13, 2014

Published In

Volume / Issue

  • 63 / 18

Start / End Page

  • 1823 - 1832

PubMed ID

  • 24613328

Pubmed Central ID

  • 24613328

Electronic International Standard Serial Number (EISSN)

  • 1558-3597

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2014.01.051

Language

  • eng

Conference Location

  • United States