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Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging.

Publication ,  Journal Article
Sipkins, DA; Cheresh, DA; Kazemi, MR; Nevin, LM; Bednarski, MD; Li, KC
Published in: Nat Med
May 1998

Angiogenesis, the formation of new blood vessels, is a requirement for malignant tumor growth and metastasis. In the absence of angiogenesis, local tumor expansion is suppressed at a few millimeters and cells lack routes for distant hematogenous spread. Clinical studies have demonstrated that the degree of angiogenesis is correlated with the malignant potential of several cancers, including breast cancer and malignant melanoma. Moreover, the expression of a specific angiogenesis marker, the endothelial integrin alphaVbeta3, has been shown to correlate with tumor grade. However, studies of tumor angiogenesis such as these have generally relied on invasive procedures, adequate tissue sampling and meticulous estimation of histologic microvessel density. In the present report, we describe a novel approach to detecting angiogenesis in vivo using magnetic resonance imaging (MRI) and a paramagnetic contrast agent targeted to endothelial alphaVbeta3 via the LM609 monoclonal antibody. This approach provided enhanced and detailed imaging of rabbit carcinomas by directly targeting paramagnetic agents to the angiogenic vasculature. In addition, angiogenic 'hot spots' not seen by standard MRI were detected. Our strategy for MR imaging of alphaVbeta3 thus represents a non-invasive means to assess the growth and malignant phenotype of tumors.

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Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

May 1998

Volume

4

Issue

5

Start / End Page

623 / 626

Location

United States

Related Subject Headings

  • Receptors, Vitronectin
  • Rabbits
  • Neovascularization, Pathologic
  • Molecular Probes
  • Magnetic Resonance Imaging
  • Immunology
  • Contrast Media
  • Carcinoma
  • Antibodies, Monoclonal
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sipkins, D. A., Cheresh, D. A., Kazemi, M. R., Nevin, L. M., Bednarski, M. D., & Li, K. C. (1998). Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nat Med, 4(5), 623–626. https://doi.org/10.1038/nm0598-623
Sipkins, D. A., D. A. Cheresh, M. R. Kazemi, L. M. Nevin, M. D. Bednarski, and K. C. Li. “Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging.Nat Med 4, no. 5 (May 1998): 623–26. https://doi.org/10.1038/nm0598-623.
Sipkins DA, Cheresh DA, Kazemi MR, Nevin LM, Bednarski MD, Li KC. Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nat Med. 1998 May;4(5):623–6.
Sipkins, D. A., et al. “Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging.Nat Med, vol. 4, no. 5, May 1998, pp. 623–26. Pubmed, doi:10.1038/nm0598-623.
Sipkins DA, Cheresh DA, Kazemi MR, Nevin LM, Bednarski MD, Li KC. Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nat Med. 1998 May;4(5):623–626.

Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

May 1998

Volume

4

Issue

5

Start / End Page

623 / 626

Location

United States

Related Subject Headings

  • Receptors, Vitronectin
  • Rabbits
  • Neovascularization, Pathologic
  • Molecular Probes
  • Magnetic Resonance Imaging
  • Immunology
  • Contrast Media
  • Carcinoma
  • Antibodies, Monoclonal
  • Animals