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ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging.

Publication ,  Journal Article
Sipkins, DA; Gijbels, K; Tropper, FD; Bednarski, M; Li, KC; Steinman, L
Published in: J Neuroimmunol
April 3, 2000

The expression of leukocyte adhesion molecules in the intact brains of mice with experimental autoimmune encephalitis (EAE) was visualized by Magnetic Resonance Imaging (MRI) through the use of a new, target-specific MR contrast agent. Antibody-conjugated paramagnetic liposomes (ACPLs) were designed to achieve in vivo targeting of molecules expressed on vascular endothelium, while providing sufficient signal enhancement at these sites for detection by MRI. ACPLs targeted to intercellular adhesion molecule-1 (ICAM-1), an endothelial leukocyte receptor upregulated on cerebral microvasculature during EAE, were administered to diseased mice. Fluorescence microscopy confirmed that fluorescently-tagged ACPLs were localized to central nervous system (CNS) microvasculature in a pattern consistent with ICAM-1 upregulation described immunohistochemically. High resolution MRI of mouse brains ex vivo demonstrated that ACPL binding conferred significant enhancement of signal intensity (SI) as compared to control images. These results suggest that ACPLs can be used as MRI contrast agents to visualize specific molecules expressed on vascular endothelium during disease.

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Published In

J Neuroimmunol

DOI

ISSN

0165-5728

Publication Date

April 3, 2000

Volume

104

Issue

1

Start / End Page

1 / 9

Location

Netherlands

Related Subject Headings

  • Tissue Distribution
  • Neurology & Neurosurgery
  • Microscopy, Fluorescence
  • Mice, Inbred Strains
  • Mice
  • Magnetic Resonance Imaging
  • Liposomes
  • Intercellular Adhesion Molecule-1
  • Gadolinium
  • Endothelium, Vascular
 

Citation

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Sipkins, D. A., Gijbels, K., Tropper, F. D., Bednarski, M., Li, K. C., & Steinman, L. (2000). ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging. J Neuroimmunol, 104(1), 1–9. https://doi.org/10.1016/s0165-5728(99)00248-9
Sipkins, D. A., K. Gijbels, F. D. Tropper, M. Bednarski, K. C. Li, and L. Steinman. “ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging.J Neuroimmunol 104, no. 1 (April 3, 2000): 1–9. https://doi.org/10.1016/s0165-5728(99)00248-9.
Sipkins DA, Gijbels K, Tropper FD, Bednarski M, Li KC, Steinman L. ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging. J Neuroimmunol. 2000 Apr 3;104(1):1–9.
Sipkins, D. A., et al. “ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging.J Neuroimmunol, vol. 104, no. 1, Apr. 2000, pp. 1–9. Pubmed, doi:10.1016/s0165-5728(99)00248-9.
Sipkins DA, Gijbels K, Tropper FD, Bednarski M, Li KC, Steinman L. ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging. J Neuroimmunol. 2000 Apr 3;104(1):1–9.
Journal cover image

Published In

J Neuroimmunol

DOI

ISSN

0165-5728

Publication Date

April 3, 2000

Volume

104

Issue

1

Start / End Page

1 / 9

Location

Netherlands

Related Subject Headings

  • Tissue Distribution
  • Neurology & Neurosurgery
  • Microscopy, Fluorescence
  • Mice, Inbred Strains
  • Mice
  • Magnetic Resonance Imaging
  • Liposomes
  • Intercellular Adhesion Molecule-1
  • Gadolinium
  • Endothelium, Vascular