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Paramagnetic polymerized liposomes as new recirculating MR contrast agents.

Publication ,  Journal Article
Storrs, RW; Tropper, FD; Li, HY; Song, CK; Sipkins, DA; Kuniyoshi, JK; Bednarski, MD; Strauss, HW; Li, KC
Published in: J Magn Reson Imaging
1995

We describe a well-tolerated blood pool contrast agent with extended recirculatory half-life based on paramagnetic polymerized liposomes (PPLs). PPLs were constructed from a new type of polymerizable lipid molecule that has a derivative of gadopentetate dimeglumine as the hydrophilic head group and diacetylene groups in the hydrophobic acyl chains, which cross-link when irradiated with ultraviolet (UV) light. Biodistribution, blood pool half-life, and MR image enhancement were determined for PPLs composed of 10% of the gadopentetate dimeglumine lipid and 90% of ditricosadiynoyl tricosadiynayl phosphatidylcholine (DAPC) at a dose of 0.015 mmol Gd+3/kg in rats. In T1-weighed MR images (TR/TE = 400/18 msec), an average signal enhancement of 34% in the kidneys and 20% in the liver was observed, which persisted for at least 90 minutes after administration of the PPLs. Biodistribution studies using radiolabeled PPLs confirmed that 80% of the injected dose remained in the blood pool after 2 hours. The half-life of elimination from the blood pool was 19 hours. The preparation was well tolerated in rats and produced similar MR contrast enhancement of the blood pool as produced by other liposome contrast agents. However, the half-life of PPL elimination from the blood pool was prolonged relative to other liposome systems.

Duke Scholars

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Published In

J Magn Reson Imaging

DOI

ISSN

1053-1807

Publication Date

1995

Volume

5

Issue

6

Start / End Page

719 / 724

Location

United States

Related Subject Headings

  • Tissue Distribution
  • Rats, Inbred Lew
  • Rats
  • Pentetic Acid
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Metabolic Clearance Rate
  • Meglumine
  • Magnetic Resonance Imaging
  • Liver
 

Citation

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Storrs, R. W., Tropper, F. D., Li, H. Y., Song, C. K., Sipkins, D. A., Kuniyoshi, J. K., … Li, K. C. (1995). Paramagnetic polymerized liposomes as new recirculating MR contrast agents. J Magn Reson Imaging, 5(6), 719–724. https://doi.org/10.1002/jmri.1880050617
Storrs, R. W., F. D. Tropper, H. Y. Li, C. K. Song, D. A. Sipkins, J. K. Kuniyoshi, M. D. Bednarski, H. W. Strauss, and K. C. Li. “Paramagnetic polymerized liposomes as new recirculating MR contrast agents.J Magn Reson Imaging 5, no. 6 (1995): 719–24. https://doi.org/10.1002/jmri.1880050617.
Storrs RW, Tropper FD, Li HY, Song CK, Sipkins DA, Kuniyoshi JK, et al. Paramagnetic polymerized liposomes as new recirculating MR contrast agents. J Magn Reson Imaging. 1995;5(6):719–24.
Storrs, R. W., et al. “Paramagnetic polymerized liposomes as new recirculating MR contrast agents.J Magn Reson Imaging, vol. 5, no. 6, 1995, pp. 719–24. Pubmed, doi:10.1002/jmri.1880050617.
Storrs RW, Tropper FD, Li HY, Song CK, Sipkins DA, Kuniyoshi JK, Bednarski MD, Strauss HW, Li KC. Paramagnetic polymerized liposomes as new recirculating MR contrast agents. J Magn Reson Imaging. 1995;5(6):719–724.
Journal cover image

Published In

J Magn Reson Imaging

DOI

ISSN

1053-1807

Publication Date

1995

Volume

5

Issue

6

Start / End Page

719 / 724

Location

United States

Related Subject Headings

  • Tissue Distribution
  • Rats, Inbred Lew
  • Rats
  • Pentetic Acid
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Metabolic Clearance Rate
  • Meglumine
  • Magnetic Resonance Imaging
  • Liver