Beyond angiogenesis: the role of endothelium in the bone marrow vascular niche.

Conference Paper

Specific tissue microenvironments, or niches, are critical for homing and maintenance of both stem cells and tumor cells in vivo. Little is known, however, about the molecular interactions between individual cells within these microenvironments. Recent studies that describe a newly identified hematopoietic stem and tumor cell vascular niche in the bone marrow (BM) suggest a critical role for vascular endothelial cell signaling and raise the possibility that bidirectional interactions of these cells with the vasculature regulate the niche dynamically. The mechanisms that govern hematopoietic stem cell (HSC)/tumor cell cross-talk with endothelial cells provide a promising new direction for future studies. Here we review recent advances that open new avenues of study in this field.

Full Text

Duke Authors

Cited Authors

  • Colmone, A; Sipkins, DA

Published Date

  • January 2008

Published In

Volume / Issue

  • 151 / 1

Start / End Page

  • 1 - 9

PubMed ID

  • 18061122

International Standard Serial Number (ISSN)

  • 1931-5244

Digital Object Identifier (DOI)

  • 10.1016/j.trsl.2007.09.003

Conference Location

  • United States