Modulation of HIV-1 immunity by adjuvants.

Journal Article (Journal Article;Review)

PURPOSE OF REVIEW: To summarize the role of adjuvants in eliciting desirable antibody responses against HIV-1 with particular emphasis on both historical context and recent developments. RECENT FINDINGS: Increased understanding of the role of pattern recognition receptors such as Toll-like receptors in recruiting and directing the immune system has increased the variety of adjuvant formulations being tested in animal models and humans. Across all vaccine platforms, adjuvant formulations have been shown to enhance desirable immune responses such as higher antibody titers and increased functional activity. Although no vaccine formulation has yet succeeded in eliciting broad neutralizing antibodies against HIV-1, the ability of adjuvants to direct the immune response to immunogens suggests they will be critically important in any successful HIV-1 vaccine. SUMMARY: The parallel development of adjuvants along with better HIV-1 immunogens will be needed for a successful AIDS vaccine. Additional comparative testing will be required to determine the optimal adjuvant and immunogen regimen that can elicit antibody responses capable of blocking HIV-1 transmission.

Full Text

Duke Authors

Cited Authors

  • Moody, MA

Published Date

  • May 2014

Published In

Volume / Issue

  • 9 / 3

Start / End Page

  • 242 - 249

PubMed ID

  • 24670321

Pubmed Central ID

  • PMC3984023

Electronic International Standard Serial Number (EISSN)

  • 1746-6318

Digital Object Identifier (DOI)

  • 10.1097/COH.0000000000000052


  • eng

Conference Location

  • United States