Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program.
PF-03084014, a γ-secretase inhibitor, was tested against the PPTP in vitro cell line panel (1.0 nM to 10 μM) and against the in vivo xenograft panels (administered orally twice daily on Days 1-7 and 15-21). PF-03084014 demonstrated limited in vitro activity, with no cell line achieving ≥50% inhibition. PF-03084014 induced significant differences in EFS distribution in 14 of 35 (40%) solid tumor xenografts, and 1 of 9 ALL xenografts (which lacked a NOTCH1 mutation), but objective responses were not observed. PF-03084014 demonstrated limited single agent activity in vitro and in vivo against the pediatric preclinical models studied.
Carol, H; Maris, JM; Kang, MH; Reynolds, CP; Kolb, EA; Gorlick, R; Keir, ST; Wu, J; Kurmasheva, RT; Houghton, PJ; Smith, MA; Lock, RB; Lyalin, D
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