Nuclear receptors as potential therapeutic targets for age-related macular degeneration.


Journal Article

Age-related macular degeneration (AMD) is the most important cause of blindness and visual impairment among the elderly. Nuclear receptors represent one of the largest families of transcription factors, with 48 present in the human genome. They are critical regulators and modulators of developmental and physiological processes and are both targets of drugs and chemicals of environmental significance. Many of the cellular processes regulated by nuclear receptors are disrupted in AMD. With this in mind, we recently created a nuclear receptor atlas of retinal pigment epithelial (RPE) cells, cells affected in AMD, highlighting the expression of all the nuclear receptors. The results of which provided scaffold to study individual receptors in aging and disease. This study led to several candidate receptors that have become the focus of detailed studies regarding their mechanistic role in the eye. One example of a nuclear receptor potentially relevant to AMD pathobiology is presented.

Full Text

Duke Authors

Cited Authors

  • Malek, G

Published Date

  • 2014

Published In

Volume / Issue

  • 801 /

Start / End Page

  • 317 - 321

PubMed ID

  • 24664713

Pubmed Central ID

  • 24664713

International Standard Serial Number (ISSN)

  • 0065-2598

Digital Object Identifier (DOI)

  • 10.1007/978-1-4614-3209-8_40


  • eng

Conference Location

  • United States