Neurotrophins: transcription and translation.


Journal Article (Review)

Neurotrophins are powerful molecules. Small quantities of these secreted proteins exert robust effects on neuronal survival, synapse stabilization, and synaptic function. Key functions of the neurotrophins rely on these proteins being expressed at the right time and in the right place. This is especially true for BDNF, stimulus-inducible expression of which serves as an essential step in the transduction of a broad variety of extracellular stimuli into neuronal plasticity of physiologically relevant brain regions. Here we review the transcriptional and translational mechanisms that control neurotrophin expression with a particular focus on the activity-dependent regulation of BDNF.

Full Text

Duke Authors

Cited Authors

  • West, AE; Pruunsild, P; Timmusk, T

Published Date

  • 2014

Published In

Volume / Issue

  • 220 /

Start / End Page

  • 67 - 100

PubMed ID

  • 24668470

Pubmed Central ID

  • 24668470

International Standard Serial Number (ISSN)

  • 0171-2004

Digital Object Identifier (DOI)

  • 10.1007/978-3-642-45106-5_4


  • eng

Conference Location

  • Germany