Neurotrophins: transcription and translation.
Publication
, Journal Article
West, AE; Pruunsild, P; Timmusk, T
Published in: Handb Exp Pharmacol
2014
Neurotrophins are powerful molecules. Small quantities of these secreted proteins exert robust effects on neuronal survival, synapse stabilization, and synaptic function. Key functions of the neurotrophins rely on these proteins being expressed at the right time and in the right place. This is especially true for BDNF, stimulus-inducible expression of which serves as an essential step in the transduction of a broad variety of extracellular stimuli into neuronal plasticity of physiologically relevant brain regions. Here we review the transcriptional and translational mechanisms that control neurotrophin expression with a particular focus on the activity-dependent regulation of BDNF.
Duke Scholars
Published In
Handb Exp Pharmacol
DOI
ISSN
0171-2004
Publication Date
2014
Volume
220
Start / End Page
67 / 100
Location
Germany
Related Subject Headings
- RNA Stability
- Protein Processing, Post-Translational
- Promoter Regions, Genetic
- Nerve Growth Factors
- Humans
- Gene Expression Regulation
- DNA Methylation
- Brain-Derived Neurotrophic Factor
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
West, A. E., Pruunsild, P., & Timmusk, T. (2014). Neurotrophins: transcription and translation. Handb Exp Pharmacol, 220, 67–100. https://doi.org/10.1007/978-3-642-45106-5_4
West, A. E., P. Pruunsild, and T. Timmusk. “Neurotrophins: transcription and translation.” Handb Exp Pharmacol 220 (2014): 67–100. https://doi.org/10.1007/978-3-642-45106-5_4.
West AE, Pruunsild P, Timmusk T. Neurotrophins: transcription and translation. Handb Exp Pharmacol. 2014;220:67–100.
West, A. E., et al. “Neurotrophins: transcription and translation.” Handb Exp Pharmacol, vol. 220, 2014, pp. 67–100. Pubmed, doi:10.1007/978-3-642-45106-5_4.
West AE, Pruunsild P, Timmusk T. Neurotrophins: transcription and translation. Handb Exp Pharmacol. 2014;220:67–100.
Published In
Handb Exp Pharmacol
DOI
ISSN
0171-2004
Publication Date
2014
Volume
220
Start / End Page
67 / 100
Location
Germany
Related Subject Headings
- RNA Stability
- Protein Processing, Post-Translational
- Promoter Regions, Genetic
- Nerve Growth Factors
- Humans
- Gene Expression Regulation
- DNA Methylation
- Brain-Derived Neurotrophic Factor
- Animals