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Neurotrophins: transcription and translation.

Publication ,  Journal Article
West, AE; Pruunsild, P; Timmusk, T
Published in: Handb Exp Pharmacol
2014

Neurotrophins are powerful molecules. Small quantities of these secreted proteins exert robust effects on neuronal survival, synapse stabilization, and synaptic function. Key functions of the neurotrophins rely on these proteins being expressed at the right time and in the right place. This is especially true for BDNF, stimulus-inducible expression of which serves as an essential step in the transduction of a broad variety of extracellular stimuli into neuronal plasticity of physiologically relevant brain regions. Here we review the transcriptional and translational mechanisms that control neurotrophin expression with a particular focus on the activity-dependent regulation of BDNF.

Duke Scholars

Published In

Handb Exp Pharmacol

DOI

ISSN

0171-2004

Publication Date

2014

Volume

220

Start / End Page

67 / 100

Location

Germany

Related Subject Headings

  • RNA Stability
  • Protein Processing, Post-Translational
  • Promoter Regions, Genetic
  • Nerve Growth Factors
  • Humans
  • Gene Expression Regulation
  • DNA Methylation
  • Brain-Derived Neurotrophic Factor
  • Animals
 

Citation

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West, A. E., Pruunsild, P., & Timmusk, T. (2014). Neurotrophins: transcription and translation. Handb Exp Pharmacol, 220, 67–100. https://doi.org/10.1007/978-3-642-45106-5_4
West, A. E., P. Pruunsild, and T. Timmusk. “Neurotrophins: transcription and translation.Handb Exp Pharmacol 220 (2014): 67–100. https://doi.org/10.1007/978-3-642-45106-5_4.
West AE, Pruunsild P, Timmusk T. Neurotrophins: transcription and translation. Handb Exp Pharmacol. 2014;220:67–100.
West, A. E., et al. “Neurotrophins: transcription and translation.Handb Exp Pharmacol, vol. 220, 2014, pp. 67–100. Pubmed, doi:10.1007/978-3-642-45106-5_4.
West AE, Pruunsild P, Timmusk T. Neurotrophins: transcription and translation. Handb Exp Pharmacol. 2014;220:67–100.

Published In

Handb Exp Pharmacol

DOI

ISSN

0171-2004

Publication Date

2014

Volume

220

Start / End Page

67 / 100

Location

Germany

Related Subject Headings

  • RNA Stability
  • Protein Processing, Post-Translational
  • Promoter Regions, Genetic
  • Nerve Growth Factors
  • Humans
  • Gene Expression Regulation
  • DNA Methylation
  • Brain-Derived Neurotrophic Factor
  • Animals