Metabolic tinkering by the gut microbiome: Implications for brain development and function.


Journal Article (Review)

Brain development is an energy demanding process that relies heavily upon diet derived nutrients. Gut microbiota enhance the host's ability to extract otherwise inaccessible energy from the diet via fermentation of complex oligosaccharides in the colon. This nutrient yield is estimated to contribute up to 10% of the host's daily caloric requirement in humans and fluctuates in response to environmental variations. Research over the past decade has demonstrated a surprising role for the gut microbiome in normal brain development and function. In this review we postulate that perturbations in the gut microbial-derived nutrient supply, driven by environmental variation, profoundly impacts upon normal brain development and function.

Full Text

Duke Authors

Cited Authors

  • Selkrig, J; Wong, P; Zhang, X; Pettersson, S

Published Date

  • May 2014

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 369 - 380

PubMed ID

  • 24685620

Pubmed Central ID

  • 24685620

Electronic International Standard Serial Number (EISSN)

  • 1949-0984

Digital Object Identifier (DOI)

  • 10.4161/gmic.28681


  • eng

Conference Location

  • United States