β-cell dysfunction in adolescents and adults with newly diagnosed type 2 diabetes mellitus.

Published

Journal Article

OBJECTIVE: To compare β-cell function in adolescents and adults with newly diagnosed type 2 diabetes (T2DM). STUDY DESIGN: Thirty-nine adolescents with T2DM, 38 age- and weight-matched control subjects, and 19 adults with T2DM were studied. The adolescent subjects with diabetes were divided on the basis of whether they needed insulin to control their initial hyperglycemia. The primary outcome variable was the disposition index, computed from the acute insulin response to glucose corrected for insulin sensitivity (1/Homeostatic model assessment of insulin resistance). RESULTS: The disposition index was significantly reduced in all 3 diabetic groups (control n=3360, adolescents with T2DM without insulin n=630, adolescents with T2DM with insulin n=120, adults with T2DM n=200; P<.001), and the adolescents with more severe hyperglycemia at diagnosis had lower disposition index than those with a more modest presentation (P<.05). CONCLUSION: At the time of diagnosis, adolescents with T2DM have significant β-cell dysfunction, comparable with adults newly diagnosed with T2DM. Thus, severe β-cell impairment can develop within the first two decades of life and is likely to play a central role in the pathogenesis of T2DM in adolescents.

Full Text

Duke Authors

Cited Authors

  • Elder, DA; Herbers, PM; Weis, T; Standiford, D; Woo, JG; D'Alessio, DA

Published Date

  • June 2012

Published In

Volume / Issue

  • 160 / 6

Start / End Page

  • 904 - 910

PubMed ID

  • 22240107

Pubmed Central ID

  • 22240107

Electronic International Standard Serial Number (EISSN)

  • 1097-6833

Digital Object Identifier (DOI)

  • 10.1016/j.jpeds.2011.12.002

Language

  • eng

Conference Location

  • United States