Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats.
Journal Article (Journal Article)
Bariatric surgery is the most efficacious procedure for eliciting weight loss in humans, and many patients undergoing the procedure experience significant lessening of their symptoms of type-2 diabetes in addition to losing weight. We have adapted two bariatric surgical procedures commonly employed in humans to a rat model to begin to understand the mechanisms underlying the improvements in energy homeostasis. Young adult male rats received either roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG) and were assessed for body weight, food intake and parameters of glucose homeostasis over a 28-week period. Control rats received either a sham surgical procedure or else were unoperated. RYGB and VSG had comparable beneficial effects relative to controls. They ate less food and lost more weight, and they both had improved glucose parameters. The most intriguing aspect of the findings is that the two surgical procedures had such similar effects in spite of quite different rearrangements of the gastrointestinal system.
Full Text
Duke Authors
Cited Authors
- Chambers, AP; Stefater, MA; Wilson-Perez, HE; Jessen, L; Sisley, S; Ryan, KK; Gaitonde, S; Sorrell, JE; Toure, M; Berger, J; D'Alessio, DA; Sandoval, DA; Seeley, RJ; Woods, SC
Published Date
- November 30, 2011
Published In
Volume / Issue
- 105 / 1
Start / End Page
- 120 - 123
PubMed ID
- 21683726
Pubmed Central ID
- PMC3852684
Electronic International Standard Serial Number (EISSN)
- 1873-507X
Digital Object Identifier (DOI)
- 10.1016/j.physbeh.2011.05.026
Language
- eng
Conference Location
- United States