GLP-1 and energy balance: an integrated model of short-term and long-term control.

Journal Article (Review)

Glucagon-like peptide 1 (GLP-1), a peptide secreted from the intestine in response to nutrient ingestion, is perhaps best known for its effect on glucose-stimulated insulin secretion. GLP-1 is also secreted from neurons in the caudal brainstem, and it is well-established that, in rodents, central administration of GLP-1 potently reduces food intake. Over the past decade, GLP-1 has emerged not only as an essential component of the system that regulates blood glucose levels but also as a viable therapeutic target for the treatment of type 2 diabetes mellitus. However, although GLP-1 receptor agonists are known to produce modest but statistically significant weight loss in patients with diabetes mellitus, our knowledge of how endogenous GLP-1 regulates food intake and body weight remains limited. The purpose of this Review is to discuss the evolution of our understanding of how endogenous GLP-1 modulates energy balance. Specifically, we consider contributions of both central and peripheral GLP-1 and propose an integrated model of short-term and long-term control of energy balance. Finally, we discuss this model with respect to current GLP-1-based therapies and suggest ongoing research in order to maximize the effectiveness of GLP-1-based treatment of obesity.

Full Text

Duke Authors

Cited Authors

  • Barrera, JG; Sandoval, DA; D'Alessio, DA; Seeley, RJ

Published Date

  • June 7, 2011

Published In

Volume / Issue

  • 7 / 9

Start / End Page

  • 507 - 516

PubMed ID

  • 21647189

Electronic International Standard Serial Number (EISSN)

  • 1759-5037

International Standard Serial Number (ISSN)

  • 1759-5029

Digital Object Identifier (DOI)

  • 10.1038/nrendo.2011.77

Language

  • eng