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Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese women.

Publication ,  Journal Article
Gray, DL; O'Brien, KD; D'Alessio, DA; Brehm, BJ; Deeg, MA
Published in: Metabolism
April 2008

Although circulating glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD), a minor high-density lipoprotein-associated protein, is elevated in patients with insulin resistance or high triglycerides, no information is available on the effect of weight loss or changes in insulin sensitivity on circulating GPI-PLD levels. The objective of the study was to determine the effect of weight loss and changes in insulin sensitivity on plasma GPI-PLD levels. Forty-two nondiabetic obese women were included in the study, which involved a 3-month dietary intervention randomizing patients to a low-fat or a low-carbohydrate diet. The study's main outcome measures were plasma GPI-PLD levels and insulin sensitivity as estimated by the homeostasis model assessment. The very low carbohydrate diet group lost more weight after 3 months (-7.6 +/- 3.2 vs -4.2 +/- 3.5 kg, P < .01), although the decrease in insulin resistance was similar between groups. Weight loss with either diet did not alter plasma GPI-PLD levels. However, baseline GPI-PLD levels correlated with the change in insulin sensitivity in response to the low-fat diet, whereas baseline insulin sensitivity correlated with the change in insulin sensitivity in response to the low-carbohydrate diet. Plasma GPI-PLD may serve as a clinical tool to determine the effect of a low-fat diet on insulin sensitivity.

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Published In

Metabolism

DOI

ISSN

0026-0495

Publication Date

April 2008

Volume

57

Issue

4

Start / End Page

473 / 478

Location

United States

Related Subject Headings

  • Weight Loss
  • Phospholipase D
  • Obesity
  • Middle Aged
  • Insulin Resistance
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diet, Fat-Restricted
  • Diet, Carbohydrate-Restricted
 

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Gray, D. L., O’Brien, K. D., D’Alessio, D. A., Brehm, B. J., & Deeg, M. A. (2008). Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese women. Metabolism, 57(4), 473–478. https://doi.org/10.1016/j.metabol.2007.11.007
Gray, Dona L., Kevin D. O’Brien, David A. D’Alessio, Bonnie J. Brehm, and Mark A. Deeg. “Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese women.Metabolism 57, no. 4 (April 2008): 473–78. https://doi.org/10.1016/j.metabol.2007.11.007.
Gray, Dona L., et al. “Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese women.Metabolism, vol. 57, no. 4, Apr. 2008, pp. 473–78. Pubmed, doi:10.1016/j.metabol.2007.11.007.
Journal cover image

Published In

Metabolism

DOI

ISSN

0026-0495

Publication Date

April 2008

Volume

57

Issue

4

Start / End Page

473 / 478

Location

United States

Related Subject Headings

  • Weight Loss
  • Phospholipase D
  • Obesity
  • Middle Aged
  • Insulin Resistance
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diet, Fat-Restricted
  • Diet, Carbohydrate-Restricted