The contribution of enteroinsular hormones to the pathogenesis of type 2 diabetes mellitus.

Journal Article (Journal Article;Review)

The gastrointestinal hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), termed incretins, are essential regulators of normal glucose homeostasis. Research indicates that the incretin effect is impaired in type 2 diabetes, and this seems to be a consequence rather than a cause of type 2 diabetes. This review describes the defects in the incretin system seen in diabetic patients and discusses the potential roles of GIP and GLP-1 in the pathogenesis of type 2 diabetes. In addition, new information on clinical applications that exploit the enteroinsular axis to control blood glucose is discussed.

Full Text

Duke Authors

Cited Authors

  • Diab, DL; D'Alessio, DA

Published Date

  • June 2010

Published In

Volume / Issue

  • 10 / 3

Start / End Page

  • 192 - 198

PubMed ID

  • 20425582

Electronic International Standard Serial Number (EISSN)

  • 1539-0829

Digital Object Identifier (DOI)

  • 10.1007/s11892-010-0114-6


  • eng

Conference Location

  • United States