Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei.

Journal Article (Journal Article)

Glucagon-like peptide-1 (GLP-1) plays a role in modulating neuroendocrine and autonomic function. The hypothalamic paraventricular nucleus (PVN) contains aggregations of GLP-1 fibers and expresses GLP-1 receptors, making it a likely site of action for GLP-1 signaling. The current study was designed to establish domains of GLP-1 action, focusing on axosomatic appositions on different neuroendocrine and autonomic cell populations in the PVN. The data indicate abundant GLP-1-immunoreactive terminal appositions on corticotropin-releasing hormone neurons in the medial parvocellular PVN. GLP-1 positive boutons can also be observed in apposition to oxytocinergic neurons and on retrogradely labeled pre-autonomic neurons projecting to the region of the nucleus of the solitary tract. In contrast, there were very few vasopressinergic neurons with GLP-1 appositions. Overall, the data indicate that the central GLP-1 system preferentially targets neurons in hypophysiotrophic zones of the PVN, consistent with excitatory actions of GLP-1 on adrenocorticotropin release. GLP-1 is also in position to influence oxytocin secretion and control outflow to brainstem cardiovascular relays.

Full Text

Duke Authors

Cited Authors

  • Tauchi, M; Zhang, R; D'Alessio, DA; Stern, JE; Herman, JP

Published Date

  • December 2008

Published In

Volume / Issue

  • 36 / 3-4

Start / End Page

  • 144 - 149

PubMed ID

  • 18773953

Pubmed Central ID

  • PMC2646608

International Standard Serial Number (ISSN)

  • 0891-0618

Digital Object Identifier (DOI)

  • 10.1016/j.jchemneu.2008.07.009


  • eng

Conference Location

  • Netherlands